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Substance Name: Synthetase, (2'-5')-oligoadenylate
RN: 69106-44-1


  • An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
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Names and Synonyms

MeSH Heading

  • 2',5'-Oligoadenylate Synthetase


  • 2-5A Synthetase
  • A glactose-specific lectin from sponge - Chondrilla nucula
  • Chondrilla nucula lectin
  • Oligoisoadenylate synthetase

Systematic Name

  • Synthetase, (2'-5')-oligoadenylate

Registry Numbers

CAS Registry Number

  • 69106-44-1

System Generated Number

  • 0069106441