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Substance Name: Fialuridine [USAN:INN]
RN: 69123-98-4
UNII: 53T7IN77LC
InChIKey: IPVFGAYTKQKGBM-BYPJNBLXSA-N

Classification Codes

  • Anti-Infective Agents
  • Antiviral
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Molecular Formula

  • C9-H10-F-I-N2-O5

Molecular Weight

  • 372.085
 
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Names and Synonyms

Name of Substance

  • Fialuridine
  • Fialuridine [USAN:INN]

Synonyms

  • 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil
  • 2'-Fluoro-5-iodo-1-beta-D-arabinofuranosyluracil
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-
  • DRG-0098
  • Fialuridine
  • FIAU
  • Fluoroiodoarauridine
  • UNII-53T7IN77LC
  • Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-

Systematic Names

  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-
  • Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-

Registry Numbers

CAS Registry Number

  • 69123-98-4

FDA UNII

  • 53T7IN77LC

System Generated Number

  • 0069123984

Structure Descriptors

InChI

1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1

InChIKey

IPVFGAYTKQKGBM-BYPJNBLXSA-N

Smiles

c1c(c(=O)[nH]c(=O)n1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 9100ug/kg/13W (9.1mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

LIVER: LIVER FUNCTION TESTS IMPAIRED
New England Journal of Medicine. Vol. 333, Pg. 1099, 1995.