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Substance Name: Arbaclofen [USAN:INN]
RN: 69308-37-8
UNII: NYU6UTW25B
InChIKey: KPYSYYIEGFHWSV-QMMMGPOBSA-N

Note

  • A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Molecular Formula

  • C10-H12-Cl-N-O2

Molecular Weight

  • 213.6628
 

Classification Code

  • Treatment of Fragile X Syndrome and Autism
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Names and Synonyms

Name of Substance

  • Arbaclofen [USAN:INN]

Synonyms

  • (-)-Baclofen
  • (R)-(-)-Baclofen
  • (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
  • (R)-Baclofen
  • Arbaclofen
  • D-Baclofen
  • R-(-)-Baclofen
  • R-Baclofen
  • STX 209
  • STX209
  • UNII-NYU6UTW25B

Systematic Names

  • Benzeneporopanoic acid, (beta-(aminomethyl)-4-chloro-, (betaR)-
  • Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (R)-

Registry Numbers

CAS Registry Number

  • 69308-37-8

FDA UNII

  • NYU6UTW25B

System Generated Number

  • 0069308378

Structure Descriptors

InChI

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1

InChIKey

KPYSYYIEGFHWSV-QMMMGPOBSA-N

Smiles

c1cc(ccc1[C@@H](CC(=O)O)CN)Cl