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Substance Name: Sulbactam sodium [USAN:USP:JAN]
RN: 69388-84-7
UNII: DKQ4T82YE6
InChIKey: NKZMPZCWBSWAOX-IBTYICNHSA-M

Note

  • A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

Molecular Formula

  • C8-H11-N-O5-S.Na

Molecular Weight

  • 255.225
 

Classification Codes

  • Drug / Therapeutic Agent
  • Inhibitor (beta-Lactamase)
  • Reproductive Effect
  • Synergist (Penicillin/Cephalosporin)
  • Synergist (Penicillincephalosporin)
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Names and Synonyms

Name of Substance

  • Sulbactam sodium [USAN:USP:JAN]

Synonyms

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S-cis)-
  • CP 45899 sodium salt
  • CP 45899-2
  • CP-45,899-2
  • EINECS 273-984-4
  • Penicillanic acid 1,1-dioxide sodium salt
  • Penicillanic acid dioxide sodium salt
  • Penicillanic acid sulfone sodium salt
  • Sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-dioxide
  • Sodium 1,1-dioxopenicillanate
  • Sodium penicillanate 1,1-dioxide
  • Sodium sulbactam
  • Sulbactam natrium
  • Sulbactam sodium
  • UNII-DKQ4T82YE6

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S-cis)-
  • Sodium (2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-dioxide

Mixture Name

  • Unasyn

Registry Numbers

CAS Registry Number

  • 69388-84-7

FDA UNII

  • DKQ4T82YE6

System Generated Number

  • 0069388847

Molecular Formulas

Molecular Formula

  • C8-H11-N-O5-S.Na

Molecular Formula Fragments

  • C8-H11-N-O5-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C8H11NO5S.Na/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14;/h5-6H,3H2,1-2H3,(H,11,12);/q;+1/p-1/t5-,6+;/m1./s1

InChIKey

NKZMPZCWBSWAOX-IBTYICNHSA-M

Smiles

[Na+].CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 32(Suppl,
mouse LD50 intravenous 8100ug/kg (8.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 32(Suppl,
rat LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 32(Suppl,
rat LD50 intravenous 6500mg/kg (6500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 32(Suppl,
rat LD50 subcutaneous > 6gm/kg (6000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 32(Suppl,