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Substance Name: Cefotetan [USAN:USP:INN:BAN]
RN: 69712-56-7
UNII: 48SPP0PA9Q
InChIKey: SRZNHPXWXCNNDU-IXOPCIAXSA-N
Note
- A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Molecular Formula
- C17-H17-N7-O8-S4
Molecular Weight
- 575.6263
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Antibiotics
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Cefotetan
- Cefotetan [USAN:USP:INN:BAN]
MeSH Heading
- Cefotetan
Synonyms
- (6R,7S)-4-((2-Carboxy-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-7-yl)carbamoyl)-1,3-dithietane-delta(sup 2,alpha)-malonamic acid
- (6R,7S)-7-(4-(Carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
- BRN 1208088
- Cefotan
- Cefotetan
- Cefotetanum
- Cefotetanum [INN-Latin]
- EINECS 274-093-3
- ICI 156,834
- ICI 156834
- UNII-48SPP0PA9Q
- YM 09330
Systematic Names
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha))-
- Cefotetan
Registry Numbers
CAS Registry Number
- 69712-56-7
FDA UNII
- 48SPP0PA9Q
Related Registry Number
- 74356-00-6 (di-hydrochloride salt)
System Generated Number
- 0069712567
Structure Descriptors
InChI
1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1InChIKey
SRZNHPXWXCNNDU-IXOPCIAXSA-NSmiles
CO[C@]1(NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 6gm/kg (6000mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 2033, 1984. | |
mouse | LD50 | intraperitoneal | 8120mg/kg (8120mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Chemotherapy Vol. 30(Suppl, |
mouse | LD50 | intravenous | 4990mg/kg (4990mg/kg) | Chemotherapy Vol. 30(Suppl, | |
mouse | LD50 | intravenous | 4990mg/kg (4990mg/kg) | BLOOD: CHANGES IN SPLEEN BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Chemotherapy Vol. 30(Suppl, |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Chemotherapy Vol. 30(Suppl, |
mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 30(Suppl, |
rat | LD50 | intraperitoneal | 8250mg/kg (8250mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN | Chemotherapy Vol. 30(Suppl, |
rat | LD50 | intravenous | 5gm/kg (5000mg/kg) | "Current Chemotherapy and Infectious Diseases, Proceedings of the 11th International Congress of Chemotherapy and the 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, 1979," Washington, DC, American Soc. for Microbiology, 1980Vol. 1, Pg. 273, 1980. | |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Chemotherapy Vol. 30(Suppl, |
rat | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 30(Suppl, |