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Substance Name: Tubocurarine chloride [USP:INN:BAN:JAN]
RN: 6989-98-6
UNII: 900961Z8VR
InChIKey: WMIZITXEJNQAQK-GGDSLZADSA-N

Note

  • A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.

Molecular Formulas

  • C37-H41-Cl-N2-O6.Cl-H.5H2-O
  • C37-H41-N2-O6.Cl-H.Cl.5H2-O

Molecular Weight

  • 771.7268
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Neuromuscular Blocking Agent
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Names and Synonyms

Name of Substance

  • Tubocurarine chloride [USP:INN:BAN:JAN]

Synonyms

  • (+)-Tubocurarine chloride hydrochloride pentahydrate
  • d-Tubocurarine chloride pentahydrate
  • Tubocurarine chloride
  • UNII-900961Z8VR

Systematic Names

  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, pentahydrate, (13aR,25aS)-
  • Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, chloride, hydrochloride, pentahydrate
  • Tubocurarine, dichloride, pentahydrate, (+)-

Registry Numbers

CAS Registry Number

  • 6989-98-6

FDA UNII

  • 900961Z8VR

Other Registry Numbers

  • 1390-11-0
  • 41354-45-4

System Generated Number

  • 0006989986

Molecular Formulas

Molecular Formulas

  • C37-H41-Cl-N2-O6.Cl-H.5H2-O
  • C37-H41-N2-O6.Cl-H.Cl.5H2-O

Molecular Formula Fragments

  • C37-H41-Cl-N2-O6
  • C37-H41-N2-O6
  • Cl
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChIKey

WMIZITXEJNQAQK-GGDSLZADSA-N

Smiles

O.O.O.O.O.Cl.[Cl-].COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 400ug/kg (0.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 395, 1956.
cat LD50 oral 18mg/kg (18mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 395, 1956.
chicken LD50 intraperitoneal 5280ug/kg (5.28mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
chicken LD50 intravenous 840ug/kg (0.84mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
man TDLo intravenous 150ug/kg (0.15mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 109, 1948.
mouse LD50 intraperitoneal 421ug/kg (0.421mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
mouse LD50 intravenous 130ug/kg (0.13mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 388, 1956.
mouse LD50 oral 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 395, 1956.
mouse LD50 subcutaneous 600ug/kg (0.6mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 333, 1950.
rabbit LD50 intravenous 146ug/kg (0.146mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 395, 1956.
rat LD50 intraperitoneal 270ug/kg (0.27mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 19, 1949.