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Substance Name: Rifamycin [USAN:INN:BAN:DCF]
RN: 6998-60-3
UNII: DU69T8ZZPA
InChIKey: HJYYPODYNSCCOU-ODRIEIDWSA-N

Classification Codes

  • Antirheumatic Agents
  • Mutation Data
  • Reproductive Effect
  • Treatment of Traveler's Diarrhea

Molecular Formula

  • C37-H47-N-O12

Molecular Weight

  • 697.7733
 
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Names and Synonyms

Name of Substance

  • Rifamycin SV
  • Rifamycin [USAN:INN:BAN:DCF]

Synonyms

  • CB-01-11
  • EINECS 230-273-3
  • M-14
  • Rifamicina
  • Rifamicina [INN-Spanish]
  • Rifamicine SV
  • Rifamycin
  • Rifamycin SV
  • Rifamycine
  • Rifamycine [INN-French]
  • Rifamycinum
  • Rifamycinum [INN-Latin]
  • Rifocin
  • Rifocyn
  • Rifomycin SV
  • UNII-DU69T8ZZPA

Systematic Names

  • 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
  • Rifamycin
  • Rifamycin SV, an antibiotic produced by certain strains of Streptomyces mediterranei, or the same substance produced by any other means

Registry Numbers

CAS Registry Number

  • 6998-60-3

FDA UNII

  • DU69T8ZZPA

Related Registry Numbers

  • 14897-39-3 (unspecified hydrochloride salt)
  • 15105-92-7 (mono-hydrochloride salt)

System Generated Number

  • 0006998603

Structure Descriptors

InChI

InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1

InChIKey

HJYYPODYNSCCOU-ODRIEIDWSA-N

Smiles

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\C(=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)\C)cc(O)c4c3C2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intracrebral 5800ug/kg (5.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Antibiotics, Series B. Vol. 16, Pg. 312, 1963.
mouse LD50 intraperitoneal 625mg/kg (625mg/kg)   Experientia. Vol. 16, Pg. 412, 1960.
mouse LD50 intravenous 450mg/kg (450mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 359, 1966.
mouse LD50 oral 2120mg/kg (2120mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 242, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 300 deg C   EXP
log P (octanol-water) 5.040 (none)   EST
Atmospheric OH Rate Constant 3.94E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.