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Substance Name: Glutathione [BAN:JAN]
RN: 70-18-8
UNII: GAN16C9B8O
InChIKey: RWSXRVCMGQZWBV-WDSKDSINSA-N

Note

  • A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Molecular Formula

  • C10-H17-N3-O6-S

Molecular Weight

  • 307.3253
 

Classification Codes

  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Glutathione
  • Glutathione [BAN:JAN]
  • Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
  • N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine

MeSH Heading

  • Glutathione

Synonyms

  • CCRIS 2094
  • Copren
  • Deltathione
  • EINECS 200-725-4
  • gamma-L-Glutamyl-L-cysteinylglycine
  • gamma-L-Glutamylcysteinylglycine
  • Glutathion
  • Glutathione
  • Glutathione (reduced)
  • Glutathione SH
  • Glutathione-SH
  • Glutatiol
  • Glutatione
  • Glutide
  • Glutinal
  • GSH
  • Isethion
  • L-Glutathione
  • L-Glutatione
  • Ledac
  • Neuthion
  • NSC 400639
  • Panaron
  • Reduced glutathione
  • Tathion
  • Tathione
  • Triptide
  • UNII-GAN16C9B8O

Systematic Names

  • Glutathione
  • Glycine, L-gamma-glutamyl-L-cysteinyl-
  • Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
  • N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine

Registry Numbers

CAS Registry Number

  • 70-18-8

FDA UNII

  • GAN16C9B8O

Other Registry Numbers

  • 1109226-07-4
  • 1655518-50-5

System Generated Number

  • 0000070188

Structure Descriptors

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChIKey

RWSXRVCMGQZWBV-WDSKDSINSA-N

Smiles

N[C@@H](CCC(=O)N[C@H](C(=O)NCC(=O)O)CS)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 4gm/kg (4000mg/kg)   "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 97, 1968.
mouse LD50 intraperitoneal 4020mg/kg (4020mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 intravenous 2238mg/kg (2238mg/kg)   Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
mouse LD50 oral 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 subcutaneous 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
rabbit LD50 intravenous > 2gm/kg (2000mg/kg)   Biochemical Journal. Vol. 41, Pg. 325, 1947.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 195 deg C   EXP
log P (octanol-water) -5.410 (none)   EST
Atmospheric OH Rate Constant 1.26E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.