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Substance Name: Terazosin hydrochloride [USAN:USP:JAN]
RN: 70024-40-7
UNII: D32S14F082
InChIKey: NZMOFYDMGFQZLS-UHFFFAOYSA-N

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H25-N5-O4.Cl-H.2H2-O

Molecular Weight

  • 459.928
 

Names and Synonyms

Name of Substance

  • Terazosin hydrochloride [USAN:USP:JAN]

Synonyms

  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine HCl 2H2O
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate
  • Abbott-45975
  • Adecur
  • Deflox
  • Dysalfa
  • Flotrin
  • Heitrin
  • Hitrin
  • Hydracin
  • Hytrin
  • Hytrine
  • Hytrinex
  • Isontyn
  • Itrin
  • Magnurol
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, monohydrochloride, dihydrate
  • Sinalfa
  • Teralfa
  • Teraprost
  • Terazosin Abbot
  • Terazosin hydrochloride
  • Terazosin hydrochloride dihydrate
  • Terazosin monohydrochloride dihydrate
  • UNII-D32S14F082
  • Unoprost
  • Urodie
  • Uroflo
  • Vicard

Systematic Name

  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, monohydrochloride, dihydrate

Registry Numbers

CAS Registry Number

  • 70024-40-7

FDA UNII

  • D32S14F082

Related Registry Number

  • 63590-64-7 (Parent)

System Generated Number

  • 0070024407

Molecular Formulas

Molecular Formula

  • C19-H25-N5-O4.Cl-H.2H2-O

Molecular Formula Fragments

  • C19-H25-N5-O4
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

InChIKey

NZMOFYDMGFQZLS-UHFFFAOYSA-N

Smiles

O.O.Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 237mg/kg (237mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 505, 1987.
mouse LD50 oral > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. -, Pg. 704, 1990.
mouse LD50 subcutaneous 956mg/kg (956mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 505, 1987.
rat LD50 intravenous 255mg/kg (255mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
rat LD50 oral 5500mg/kg (5500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
rat LD50 subcutaneous 1050mg/kg (1050mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 505, 1987.