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Substance Name: Eflornithine [INN:BAN]
RN: 70052-12-9
UNII: ZQN1G5V6SR
InChIKey: VLCYCQAOQCDTCN-UHFFFAOYSA-N

Note

  • An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.

Molecular Formula

  • C6-H12-F2-N2-O2

Molecular Weight

  • 182.1688
 

Classification Codes

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Ornithine Decarboxylase Inhibitors
  • Reproductive Effect
  • Trypanocidal Agents

Names and Synonyms

Name of Substance

  • Eflornithine
  • Eflornithine [INN:BAN]

MeSH Heading

  • Eflornithine

Synonyms

  • 2-(Difluoromethyl)-DL-ornithine
  • 2-(Difluoromethyl)ornithine
  • alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid
  • alpha-(Difluoromethyl)-DL-ornithine
  • alpha-Difluoromethylornithine
  • BRN 2250529
  • CCRIS 3295
  • DFMO
  • DFMO (growth regulator)
  • Difluromethylornithine
  • DL-alpha-(Difluoromethyl)ornithine
  • Eflornithine
  • Eflornithinum
  • Eflornithinum [Latin]
  • Eflornitina
  • Eflornitina [Spanish]
  • HSDB 7923
  • MDL 71782
  • N-Difluoromethylornithine
  • Ornidyl
  • RFI 7178
  • RMI 71782
  • UNII-ZQN1G5V6SR

Systematic Names

  • 2-(Difluoromethyl)ornithine
  • Ornithine, 2-(difluoromethyl)-

Registry Numbers

CAS Registry Number

  • 70052-12-9

FDA UNII

  • ZQN1G5V6SR

Other Registry Number

  • 67037-37-0

Related Registry Number

  • 96020-91-6 (mono-hydrochloride, monohydrate)

System Generated Number

  • 0070052129

Structure Descriptors

InChI

1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)

InChIKey

VLCYCQAOQCDTCN-UHFFFAOYSA-N

Smiles

C([C@@](C(O)=O)(C(F)F)N)CCN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 9084mg/kg/2W- (9084mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: THROMBOCYTOPENIA
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 627, 1987.
man TDLo oral 800mg/kg/4D-I (800mg/kg) BLOOD: THROMBOCYTOPENIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 627, 1987.
women LDLo intravenous 67mg/kg/40M-C (67mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

CARDIAC: PULSE RATE
Annals of Internal Medicine. Vol. 105, Pg. 141, 1986.