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Substance Name: Cimetidine hydrochloride [USAN:USP]
RN: 70059-30-2
UNII: WF10491673
InChIKey: QJHCNBWLPSXHBL-UHFFFAOYSA-N

Note

  • A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRINS output. It also blocks the activity of CYTOCHROME P-450 which might explain proposals for use in NEOADJUVANT THERAPY.

Molecular Formula

  • C10-H16-N6-S.Cl-H

Molecular Weight

  • 288.8053
 

Classification Codes

  • Antagonist
  • Antagonist (to Histamine H2 Receptors)
  • Human Data
  • Mutation Data

Names and Synonyms

Name of Substance

  • Cimetidine hydrochloride [USAN:USP]

MeSH Heading

  • Cimetidine

Synonyms

  • 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine monohydrochloride
  • Cimetex
  • Cimetidine HCl
  • Cimetidine hydrochloride
  • Cimetidine hydrochloride in sodium chloride 0.9% in plastic container
  • EINECS 274-297-2
  • Endo
  • Guanidine, N'-cyano-N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, monohydrochloride
  • Tagamet
  • Tagamet hydrochloride in sodium chloride 0.9% in plastic container
  • Tagamet Injection
  • Tagamet Liquid
  • UNII-WF10491673

Systematic Names

  • Guanidine, N''-cyano-N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, monohydrochloride
  • N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine monohydrochloride

Registry Numbers

CAS Registry Number

  • 70059-30-2

FDA UNII

  • WF10491673

System Generated Number

  • 0070059302

Molecular Formulas

Molecular Formula

  • C10-H16-N6-S.Cl-H

Molecular Formula Fragments

  • C10-H16-N6-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H

InChIKey

QJHCNBWLPSXHBL-UHFFFAOYSA-N

Smiles

Cc1c(nc[nH]1)CSCCN/C(=N/C#N)/NC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo intravenous 12mg/kg/6H-I (12mg/kg) BLOOD: THROMBOCYTOPENIA

BLOOD: LEUKOPENIA
Southern Medical Journal. Vol. 75, Pg. 1283, 1982.