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Substance Name: Ivermectin [USAN:USP:INN:BAN]
RN: 70288-86-7
UNII: 8883YP2R6D
InChIKey: SPBDXSGPUHCETR-VHJJIYNUSA-N
Note
- A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Molecular Formula
- C48-H74-O14.C47-H72-O14
Molecular Weight
- 1736.1704
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Infective Agents
- Antiparasitic
- Antiparasitic Agents
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Insecticides
- Natural Product
- Pesticides
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Ivermectin
- Ivermectin [USAN:USP:INN:BAN]
MeSH Heading
- Ivermectin
Synonyms
- (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pg)(2,6)benzodioxacyclooctadecin-13,2'(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
- 22,23-Dihydroavermectin B1
- Acarexx
- Agri-Mectin
- Alverin Plus for Cattle
- Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
- Bimectin
- Bimectin pour-on
- Cardomec
- Cardotek-30
- CCRIS 8839
- EINECS 274-536-0
- Endo-Mectin for Cattle and Swine
- Endo-Mectin Plus for Cattle
- Equimectrin
- Eqvalan
- Heartgard
- Heartgard-30
- Hyvermectin
- Ivermax
- Ivermectin
- Ivermectine
- Ivermectine [INN-French]
- Ivermectino
- Ivermectino [INN-Spanish]
- Ivermectinum
- Ivermectinum [INN-Latin]
- Ivomec
- L 640471
- Mectizan
- MK 933
- MK-0933
- Noromectin
- Noromectin for cattle and swine
- Oramec
- Pandex
- Phoenectin
- Sklice
- Soolantra
- Stromectol
- UNII-8883YP2R6D
- Uvemec
- Vermic
- Vetmec
- Zimecterin
Systematic Names
- 22,23-Dihydroavermectin B1
- A mixture of Ivermectin component B(sub 1a) and Ivermectin component B(sub 1b).
- Ivermectin
Mixture Names
- Heartgard-30 Plus
- Ivomec Plus
- Ivomec-F
Registry Numbers
CAS Registry Number
- 70288-86-7
FDA UNII
- 8883YP2R6D
Other Registry Numbers
- 1014990-52-3
- 118710-50-2
- 74564-75-3
System Generated Number
- 0070288867
Molecular Formulas
Molecular Formula
- C48-H74-O14.C47-H72-O14
Molecular Formula Fragments
- C47-H72-O14
- C48-H74-O14
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25?,26-,28-,30-,31-,33+,34?,35-,36-,37-,38?,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33?,34-,35-,36-,37?,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1InChIKey
SPBDXSGPUHCETR-VHJJIYNUSA-NSmiles
CCC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cattle | LDLo | subcutaneous | 8mg/kg (8mg/kg) | Science. Vol. 221, Pg. 823, 1983. | |
dog | LD50 | oral | 80mg/kg (80mg/kg) | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. | |
man | TDLo | intravenous | 571ug/kg (0.571mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. |
monkey | LD50 | oral | > 24mg/kg (24mg/kg) | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. | |
mouse | LD50 | intraperitoneal | 30mg/kg (30mg/kg) | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. | |
mouse | LD50 | oral | 25mg/kg (25mg/kg) | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. | |
rat | LD50 | intraperitoneal | 55mg/kg (55mg/kg) | Japanese Journal of Toxicology. Vol. 12, Pg. 227, 1999. | |
rat | LD50 | oral | 10mg/kg (10mg/kg) | United States Patent Document. Vol. #5006545, |