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Substance Name: 5-Fluoroorotic acid
RN: 703-95-7
UNII: 7IA9OUC93E
InChIKey: SEHFUALWMUWDKS-UHFFFAOYSA-N

Note

  • Inhibits the dietary induction of serine dehydratase.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C5-H3-F-N2-O4

Molecular Weight

  • 174.0867
 
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Names and Synonyms

Name of Substance

  • 5-Fluoroorotic acid

Synonyms

  • 1,2,3,6-Tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid
  • 5-Fluoroorotate
  • 5-Fluoroorotic acid
  • 5-Fluoroorotic acid (VAN)
  • AI3-26398
  • EINECS 211-876-0
  • ENT-26398
  • Fluoroorotic acid
  • FO
  • FOA
  • NSC 31712
  • Orotic acid, 5-fluoro-
  • Ro 2-9945
  • UNII-7IA9OUC93E
  • WR 152520

Systematic Names

  • 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-
  • 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo- (9CI)
  • 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-, monohydrate
  • 5-Fluorouracil-4-carboxylic acid
  • Orotic acid, 5-fluoro-
  • Orotic acid, 5-fluoro- (VAN) (8CI)

Registry Numbers

CAS Registry Number

  • 703-95-7

FDA UNII

  • 7IA9OUC93E

System Generated Number

  • 0000703957

Structure Descriptors

InChI

1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)

InChIKey

SEHFUALWMUWDKS-UHFFFAOYSA-N

Smiles

c1(c([nH]c(=O)[nH]c1=O)C(=O)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 981mg/kg (981mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   Advances in Teratology. Vol. 3, Pg. 181, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.060 (none)   EST
Atmospheric OH Rate Constant 4.22E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.