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Substance Name: Toxins, pertussis
RN: 70323-44-3

Note

  • One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
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Links to Resources

Names and Synonyms

MeSH Heading

  • Pertussis Toxin

Synonyms

  • Bordetella pertussis toxin
  • Histamine-sensitizing factor
  • IAP
  • Islet activating protein
  • Leukocytosis-promoting factor
  • Lymphocytosis-promoting factor
  • Pancreatic islet-activating proteins
  • Pertussigen
  • Pertussigen (Bordetella pertussis)
  • Pertussis toxins
  • Proteins, pancreatic islet-activating
  • Proteins, specific or class, pancreatic islet-activating
  • Toxins, exo-, pertussis

Systematic Name

  • Toxins, pertussis

Registry Numbers

CAS Registry Number

  • 70323-44-3

Other Registry Number

  • 82248-93-9

System Generated Number

  • 0070323443

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 17160ng/kg (0.01716mg/kg)   Infection and Immunity. Vol. 31, Pg. 495, 1981.
mouse LD50 intravenous 127ug/kg (0.127mg/kg)   Tohoku Journal of Experimental Medicine. Vol. 130, Pg. 105, 1980.
mouse LD50 intravenous 127ug/kg (0.127mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Tohoku Journal of Experimental Medicine. Vol. 130, Pg. 105, 1980.
rat LD50 intravenous 114ug/kg (0.114mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Tohoku Journal of Experimental Medicine. Vol. 130, Pg. 105, 1980.