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Substance Name: 7-N-(4-Hydroxyphenyl)mitomycin C
RN: 70343-57-6
InChIKey: HNTGDFCASLOZEZ-YDBSYXHISA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C21-H22-N4-O6

Molecular Weight

  • 426.4268
 
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Names and Synonyms

Name of Substance

  • 7-N-(4-Hydroxyphenyl)mitomycin C

Synonyms

  • 7-N-(p-Hydroxyphenyl)-mitomycin C
  • Antibiotic M83
  • KW 2083
  • M-83
  • N(6)-4-Hydroxyphenylmitomycin C

Systematic Names

  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6-(p-hydroxyanilino)-8a-methoxy-5-methyl-, 8-carbamate (ester)
  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6-((4-hydroxyphenyl)amino)-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-

Registry Numbers

CAS Registry Number

  • 70343-57-6

System Generated Number

  • 0070343576

Structure Descriptors

InChI

1S/C21H22N4O6/c1-9-15(23-10-3-5-11(26)6-4-10)18(28)14-12(8-31-20(22)29)21(30-2)19-13(24-19)7-25(21)16(14)17(9)27/h3-6,12-13,19,23-24,26H,7-8H2,1-2H3,(H2,22,29)/t12-,13+,19+,21-/m1/s1

InChIKey

HNTGDFCASLOZEZ-YDBSYXHISA-N

Smiles

CO[C@]12[C@H]3N[C@H]3CN1C4=C([C@H]2COC(=O)N)C(=O)C(=C(C)C4=O)Nc5ccc(O)cc5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 30mg/kg (30mg/kg)   Gann. Japanese Journal of Cancer Research. Vol. 73, Pg. 675, 1982.
mouse LD50 intravenous 18800ug/kg (18.8mg/kg)   Cancer Treatment Symposia. Vol. 1, Pg. 29, 1983.