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Substance Name: Bucindolol hydrochloride [USAN]
RN: 70369-47-0
UNII: SH683G4QII
InChIKey: NCEAPFRHADKEHP-UHFFFAOYSA-N

Note

  • An indolyl-tert-butyl-phenoxypropanolamine benzonitrile derivative.

Molecular Formula

  • C22-H25-N3-O2.Cl-H

Molecular Weight

  • 399.9194
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Antihypertensive
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympathomimetics
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Bucindolol
  • Bucindolol hydrochloride [USAN]

Synonyms

  • 2-(2-Hydroxy-3-((2-(3-indolyl)-1,1-dimethylethyl)amino)propoxy)benzonitrile hydrochloride
  • Benzonitrile, 2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)-, monohydrochloride
  • Bucindolol HCl
  • Bucindolol hydrochloride
  • Gencaro
  • MJ 13,105-1
  • MJ 13105-1
  • o-(2-Hydroxy-3-((2-indol-3-yl-1,1-dimethylethyl)amino)propoxy)benzonitrile monohydrochloride
  • UNII-SH683G4QII

Systematic Name

  • Benzonitrile, 2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 70369-47-0

FDA UNII

  • SH683G4QII

System Generated Number

  • 0070369470

Molecular Formulas

Molecular Formula

  • C22-H25-N3-O2.Cl-H

Molecular Formula Fragments

  • C22-H25-N3-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H25N3O2.ClH/c1-22(2,11-17-13-24-20-9-5-4-8-19(17)20)25-14-18(26)15-27-21-10-6-3-7-16(21)12-23;/h3-10,13,18,24-26H,11,14-15H2,1-2H3;1H

InChIKey

NCEAPFRHADKEHP-UHFFFAOYSA-N

Smiles

CC(C)(Cc1c[nH]c2c1cccc2)NCC(COc3ccccc3C#N)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 1, 1983.
rat LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 1, 1983.