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Substance Name: Peplomycin sulfate [USAN:JAN]
RN: 70384-29-1
UNII: 6A668951HW
InChIKey: ZHHIHQFAUZZMTG-BSVJBJGJSA-N

Note

  • An antineoplastic agent derived from BLEOMYCIN.

Molecular Formula

  • C61-H88-N18-O21-S2.H2-O4-S

Molecular Weight

  • 1571.681
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Peplomycin sulfate salt
  • Peplomycin sulfate [USAN:JAN]

Synonyms

  • 3-((S)-1'-Phenylethylamino)propylamino-bleomycin sulfate
  • Bleomycinamide, N(sup 1)-(3-((1-phenylethyl)amino)propyl)-, (S)-, sulfate (1:1) (salt)
  • CCRIS 2471
  • EINECS 274-588-4
  • N(sup 1)-(3-(((S)-(alpha-Methylbenzyl))amino)propyl)bleomycinamide sulfate (1:1) (salt)
  • NK 631
  • NK-631
  • NSC 276382
  • Pepleo
  • Pepleomycin sulfate
  • Peplomycin sulfate
  • UNII-6A668951HW

Systematic Names

  • Bleomycinamide, N(sup 1)-(3-((1-phenylethyl)amino)propyl)-, (S)-, sulfate (1:1) (salt)
  • Bleomycinamide, N1-(3-((1-phenylethyl)amino)propyl)-, (S)-, sulfate (1:1) (salt)
  • Pepleomycin sulfate
  • Peplomycin sulfate

Registry Numbers

CAS Registry Number

  • 70384-29-1

FDA UNII

  • 6A668951HW

Other Registry Numbers

  • 69880-92-8
  • 70223-26-6
  • 70732-46-6

Related Registry Number

  • 68247-85-8 (Parent)

System Generated Number

  • 0070384291

Molecular Formulas

Molecular Formula

  • C61-H88-N18-O21-S2.H2-O4-S

Molecular Formula Fragments

  • C61-H88-N18-O21-S2
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C61H88N18O21S2.H2O4S/c1-24-39(76-52(79-50(24)64)31(16-37(63)83)71-17-30(62)51(65)89)56(93)78-41(47(32-18-67-23-72-32)98-60-49(45(87)43(85)35(19-80)97-60)99-59-46(88)48(100-61(66)95)44(86)36(20-81)96-59)57(94)73-27(4)42(84)25(2)53(90)77-40(28(5)82)55(92)70-15-12-38-74-34(22-101-38)58-75-33(21-102-58)54(91)69-14-9-13-68-26(3)29-10-7-6-8-11-29;1-5(2,3)4/h6-8,10-11,18,21-23,25-28,30-31,35-36,40-49,59-60,68,71,80-82,84-88H,9,12-17,19-20,62H2,1-5H3,(H2,63,83)(H2,65,89)(H2,66,95)(H,67,72)(H,69,91)(H,70,92)(H,73,94)(H,77,90)(H,78,93)(H2,64,76,79);(H2,1,2,3,4)/t25-,26-,27+,28+,30-,31-,35-,36+,40-,41-,42-,43+,44+,45-,46-,47-,48-,49-,59+,60-;/m0./s1

InChIKey

ZHHIHQFAUZZMTG-BSVJBJGJSA-N

Smiles

Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc5nc(cs5)c6nc(cs6)C(=O)NCCCN[C@@H](C)c7ccccc7)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 50mg/kg (50mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse LD50 intraperitoneal 77mg/kg (77mg/kg)   Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 762, 1982.
mouse LD50 subcutaneous 80mg/kg (80mg/kg)   Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse LDLo intratracheal 1572ng/kg (0.001572mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) Toxicology and Applied Pharmacology. Vol. 56, Pg. 326, 1980.
rat LD50 intraperitoneal 155mg/kg (155mg/kg)   "Bleomycin: Current Status and New Development, Papers Presented in a Symposium, Oakland, CA, 1977," Carter, S.K., et al., eds., New York, Academic Press, Inc., 1978Vol. -, Pg. 311, 1978.
rat LD50 intravenous 215mg/kg (215mg/kg)   Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 762, 1982.
rat LD50 subcutaneous 199mg/kg (199mg/kg)   Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.