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Substance Name: Lortalamine [USAN:INN]
RN: 70384-91-7
UNII: 9GIR4SV22T
InChIKey: MJRPHRMGEKCADU-GMXABZIVSA-N

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H17-Cl-N2-O2

Molecular Weight

  • 292.7643
 
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Names and Synonyms

Name of Substance

  • Lortalamine
  • Lortalamine [USAN:INN]

Synonyms

  • (+-)-(4aR*,10R*,10aS*)-8-Chloro-1,2,3,4,10,10a-hexahydro-2-methyl-4a,10-(iminoethano)-4aH-(1)benzopyrano(3,2-c)pyridin-12-one
  • 4a,10-(Iminoethano)-4aH-(1)benzopyrano(3,2-c)pyridin-12-one, 8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-, (4aalpha,10alpha,10aalpha)-(+-)-
  • LM 1404
  • LM-1404
  • Lortalamine
  • UNII-9GIR4SV22T

Systematic Names

  • 4a,10-(Iminoethano)-4aH-(1)benzopyrano(3,2-c)pyridin-12-one, 1,2,3,4,10,10a-hexahydro-8-chloro-2-methyl-, (4a-alpha,10-alpha,10a-alpha)-, (+-)-
  • 4a,10-(Iminoethano)-4aH-(1)benzopyrano(3,2-c)pyridin-12-one, 8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-, (4aalpha,10alpha,10aalpha)-(+-)-

Registry Numbers

CAS Registry Number

  • 70384-91-7

FDA UNII

  • 9GIR4SV22T

System Generated Number

  • 0070384917

Structure Descriptors

InChI

1S/C15H17ClN2O2/c1-18-5-4-15-12(8-18)10(7-14(19)17-15)11-6-9(16)2-3-13(11)20-15/h2-3,6,10,12H,4-5,7-8H2,1H3,(H,17,19)/t10-,12+,15+/m1/s1

InChIKey

MJRPHRMGEKCADU-GMXABZIVSA-N

Smiles

CN1CC[C@@]23NC(=O)C[C@@H]([C@@H]2C1)c4cc(Cl)ccc4O3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 389mg/kg (389mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1655, 1985.
rat LD50 oral 1386mg/kg (1386mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1655, 1985.