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Substance Name: Pefloxacin mesylate [USAN]
RN: 70458-95-6
UNII: 5IAD0UV3FH
InChIKey: HQQSBEDKMRHYME-UHFFFAOYSA-N

Note

  • A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

Molecular Formula

  • C17-H20-F-N3-O3.C-H4-O3-S

Molecular Weight

  • 429.4666
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Pefloxacin mesylate [USAN]
  • Pefloxacin methanesulfonate

Synonyms

  • 1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate
  • 1589 mR.B.
  • 41 982 RP
  • EINECS 274-613-9
  • Pefloxacin mesylate
  • UNII-5IAD0UV3FH

Systematic Names

  • 3-Carboxy-1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxoquinoline monomethanesulphonate
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate

Registry Numbers

CAS Registry Number

  • 70458-95-6

FDA UNII

  • 5IAD0UV3FH

Related Registry Number

  • 70458-92-3 (Parent)

System Generated Number

  • 0070458956

Molecular Formulas

Molecular Formula

  • C17-H20-F-N3-O3.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C17-H20-F-N3-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C17H20FN3O3.CH4O3S/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4)

InChIKey

HQQSBEDKMRHYME-UHFFFAOYSA-N

Smiles

C1N(CCN(C1)c1c(cc2c(c1)n(CC)cc(C(O)=O)c2=O)F)C.S(=O)(=O)(O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 225mg/kg (225mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 292, Pg. 37, 1981.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 292, Pg. 37, 1981.
rat LD50 intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 292, Pg. 37, 1981.
rat LD50 oral 2500mg/kg (2500mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 292, Pg. 37, 1981.