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Substance Name: Mitoxantrone hydrochloride [USAN:USP:JAN]
RN: 70476-82-3
UNII: U6USW86RD0
InChIKey: ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Note

  • An anthracenedione-derived antineoplastic agent.

Molecular Formula

  • C22-H28-N4-O6.2Cl-H

Molecular Weight

  • 517.407
 

Classification Codes

  • Antineoplastic
  • DNA Topoisomerase II Inhibitor
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Names and Synonyms

Name of Substance

  • Mitoxantrone hydrochloride [USAN:USP:JAN]
  • Novantrone

Synonyms

  • 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthraquinone dihydrochloride
  • 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-, dihydrochloride
  • CCRIS 2592
  • CL 232,315
  • CL 232315
  • CL-232315
  • DHAD
  • EINECS 274-619-1
  • HSDB 6543
  • Immunex
  • Mitoxantrone
  • Mitoxantrone dihydrochloride
  • Mitoxantrone HCl
  • Mitoxantrone hydrochloride
  • Novantron
  • Novantrone
  • NSC 301739
  • UNII-U6USW86RD0

Systematic Names

  • 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthraquinone dihydrochloride
  • 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-, dihydrochloride
  • Mitoxantrone

Superlist Names

  • Mitoxantrone dihydrochloride
  • Mitoxantrone hydrochloride

Registry Numbers

CAS Registry Number

  • 70476-82-3

FDA UNII

  • U6USW86RD0

Related Registry Number

  • 65271-80-9 (Parent)

System Generated Number

  • 0070476823

Molecular Formulas

Molecular Formula

  • C22-H28-N4-O6.2Cl-H

Molecular Formula Fragments

  • C22-H28-N4-O6
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChIKey

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Smiles

Cl.Cl.OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal > 1200ug/kg (1.2mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
dog LD50 intravenous 375ug/kg (0.375mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
man TDLo parenteral 71ug/kg/2W-I (0.071mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Lancet. Vol. 2, Pg. 1393, 1986.
monkey LD50 intravenous > 1mg/kg (1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 intraperitoneal 15560ug/kg (15.56mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 37, Pg. 77, 1989.
mouse LD50 intravenous 9700ug/kg (9.7mg/kg)   Drugs in Japan Vol. -, Pg. 1332, 1995.
mouse LD50 oral 502mg/kg (502mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 subcutaneous 19700ug/kg (19.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rabbit LD50 skin 125mg/kg (125mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intraperitoneal 8mg/kg (8mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intravenous 4800ug/kg (4.8mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 oral 682mg/kg (682mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 skin 1640mg/kg (1640mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 subcutaneous 5500ug/kg (5.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
women TDLo intravenous 4400ug/kg/30W (4.4mg/kg) SKIN AND APPENDAGES (SKIN): NAILS: OTHER Lancet. Vol. 1, Pg. 113, 1988.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 204 deg C   EXP
log P (octanol-water) 2.280 (none)   EST
Water Solubility 7500 mg/L   EXP
Vapor Pressure 1.30E-20 mm Hg 25 EST
Henry's Law Constant 7.00E-30 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.30E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.