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Substance Name: Itazigrel [USAN:INN]
RN: 70529-35-0
UNII: N835I8CXY0
InChIKey: CIPBQTCSXVEDSG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Platelet Aggregation Inhibitor

Molecular Formula

  • C18-H14-F3-N-O2-S

Molecular Weight

  • 365.374
 
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Names and Synonyms

Name of Substance

  • Itazigrel
  • Itazigrel [USAN:INN]

Synonyms

  • 4,5-Bis(4-methoxyphenyl)-2-trifluoromethylthiazole
  • 4,5-bis(p-Methoxyphenyl)-2-(trifluoromethyl)thiazole
  • BRN 1161179
  • Itazigrel
  • Itazigrelum
  • Itazigrelum [Latin]
  • LY 108048
  • U 53059
  • U-53,059
  • UNII-N835I8CXY0

Systematic Name

  • Thiazole, 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-

Registry Numbers

CAS Registry Number

  • 70529-35-0

FDA UNII

  • N835I8CXY0

System Generated Number

  • 0070529350

Structure Descriptors

InChI

1S/C18H14F3NO2S/c1-23-13-7-3-11(4-8-13)15-16(25-17(22-15)18(19,20)21)12-5-9-14(24-2)10-6-12/h3-10H,1-2H3

InChIKey

CIPBQTCSXVEDSG-UHFFFAOYSA-N

Smiles

c1(c(c2ccc(OC)cc2)sc(n1)C(F)(F)F)c1ccc(OC)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Thrombosis and Haemostasis. Vol. 46, Pg. 26, 1981.
mouse LD50 oral > 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #4659726,