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Substance Name: Daurisoline
RN: 70553-76-3
InChIKey: BURJAQFYNVMZDV-FIRIVFDPSA-N

Note

  • Antiarrhythmic from Menispermun dahuricum.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C37-H42-N2-O6

Molecular Weight

  • 610.747
 
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Names and Synonyms

Name of Substance

  • Daurisoline

Synonyms

  • D 610
  • Daurisoline
  • O(sup 7)-Demethyldauricine

Systematic Names

  • (R-(R*,R*))-1,2,3,4-Tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-7-isoquinolinol
  • 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-, (R-(R*,R*))-

Registry Numbers

CAS Registry Number

  • 70553-76-3

System Generated Number

  • 0070553763

Structure Descriptors

InChI

1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1

InChIKey

BURJAQFYNVMZDV-FIRIVFDPSA-N

Smiles

c12[C@@H](Cc3ccc(Oc4cc(C[C@@H]5c6c(cc(OC)c(c6)O)CC[N@@]5C)ccc4O)cc3)[N@@](CCc1cc(OC)c(c2)OC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1250ug/kg (1.25mg/kg)   Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 14, Pg. 439, 1979.