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Substance Name: Mitoguazone dihydrochloride
RN: 7059-23-6
UNII: NNI098FX5Q
InChIKey: VVTBQCXLZQYGQE-JWICLDENSA-N

Note

  • Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.

Molecular Formula

  • C5-H12-N8.2Cl-H

Molecular Weight

  • 257.1276
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Mitoguazone dihydrochloride

Synonyms

  • AI3-50536
  • EINECS 230-347-5
  • Methyl glyoxal bis(amidinohydrazone) dihydrochloride
  • Methylglyoxal bis(guanylhydrazone) dihydrochloride
  • MGGH
  • Mitoguazone HCl
  • NSC 32946
  • NSC 69432
  • UNII-NNI098FX5Q

Systematic Names

  • 3,3'-(1-Methylethane-1,2-diylidene)dicarbazamidine dihydrochloride
  • Guanidine, 1,1'-((methylethanediylidene)dinitrilo)di-, dihydrochloride
  • Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-, dihydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 7059-23-6

FDA UNII

  • NNI098FX5Q

System Generated Number

  • 0007059236

Molecular Formulas

Molecular Formula

  • C5-H12-N8.2Cl-H

Molecular Formula Fragments

  • C5-H12-N8
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C5H12N8.2ClH/c1-3(11-13-5(8)9)2-10-12-4(6)7;;/h2H,1H3,(H4,6,7,12)(H4,8,9,13);2*1H/b10-2+,11-3?;;

InChIKey

VVTBQCXLZQYGQE-JWICLDENSA-N

Smiles

Cl.Cl.CC(=NNC(=N)N)\C=N\NC(=N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 75200ug/kg (75.2mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,