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Substance Name: Doxapram hydrochloride [USAN:USP:JAN]
RN: 7081-53-0
UNII: P5RU6UOQ5Y
InChIKey: ZOMBFZRWMLIDPX-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Stimulant (Respiratory)

Molecular Formula

  • C24-H30-N2-O2.Cl-H.H2-O

Molecular Weight

  • 432.9887
 
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Names and Synonyms

Name of Substance

  • Doxapram hydrochloride [USAN:USP:JAN]

Synonyms

  • (+-)-1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate
  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate
  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate
  • 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, monohydrochloride, monohydrate, (+-)-
  • AHR 619
  • AHR-619
  • Dopram
  • Doxapram HCl H2O
  • Doxapram hydrochloride
  • Doxapram hydrochloride hydrate
  • Doxapram hydrochloride monohydrate
  • UNII-P5RU6UOQ5Y

Systematic Names

  • 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, monohydrochloride, monohydrate
  • 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, monohydrochloride, monohydrate

Registry Numbers

CAS Registry Number

  • 7081-53-0

FDA UNII

  • P5RU6UOQ5Y

System Generated Number

  • 0007081530

Molecular Formulas

Molecular Formula

  • C24-H30-N2-O2.Cl-H.H2-O

Molecular Formula Fragments

  • C24-H30-N2-O2
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

InChIKey

ZOMBFZRWMLIDPX-UHFFFAOYSA-N

Smiles

CCN1CC(C(C1=O)(c2ccccc2)c3ccccc3)CCN4CCOCC4.O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 40mg/kg (40mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
dog LD50 oral 150mg/kg (150mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 225, 1972.
man TDLo intravenous 41mg/kg/24H-C (41mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Postgraduate Medical Journal. Vol. 61, Pg. 833, 1985.
mouse LD50 intraperitoneal 153mg/kg (153mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.
mouse LD50 intravenous 85mg/kg (85mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.
mouse LD50 oral 270mg/kg (270mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.
mouse LD50 subcutaneous 312mg/kg (312mg/kg)   Drugs in Japan Vol. 6, Pg. 504, 1982.
rat LD50 intraperitoneal 174mg/kg (174mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.
rat LD50 intravenous 72mg/kg (72mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.
rat LD50 oral 261mg/kg (261mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 312mg/kg (312mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 13, Pg. 242, 1968.