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Substance Name: Terodiline hydrochloride [USAN]
RN: 7082-21-5
UNII: K2ZA89W43F
InChIKey: RNGHAJVBYQPLAZ-UHFFFAOYSA-N

Classification Codes

  • Reproductive Effect
  • Vasodilator (Coronary)

Molecular Formula

  • C20-H27-N.Cl-H

Molecular Weight

  • 317.901
 
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Names and Synonyms

Name of Substance

  • Terodiline hydrochloride [USAN]

Synonyms

  • Bicor
  • Mictrol
  • Micturin
  • Micturol
  • N-t-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride
  • N-tert-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride
  • TD-758
  • Terodiline chloride
  • Terodiline HCl
  • Terodiline hydrochloride
  • UNII-K2ZA89W43F

Systematic Names

  • Benzenepropanamine, N-(1,1-dimethylethyl)-alpha-methyl-gamma-phenyl-, hydrochloride
  • Propylamine, N-tert-butyl-1-methyl-3,3-diphenyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 7082-21-5

FDA UNII

  • K2ZA89W43F

Related Registry Number

  • 15793-40-5 (Parent)

System Generated Number

  • 0007082215

Molecular Formulas

Molecular Formula

  • C20-H27-N.Cl-H

Molecular Formula Fragments

  • C20-H27-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H

InChIKey

RNGHAJVBYQPLAZ-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)C[C@@H](NC(C)(C)C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 63300ug/kg (63.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
mouse LD50 intravenous 28mg/kg (28mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
mouse LD50 intravenous 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
mouse LD50 oral 330mg/kg (330mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
mouse LD50 subcutaneous 170mg/kg (170mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
rat LD50 intravenous 27mg/kg (27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
rat LD50 oral 465mg/kg (465mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.
rat LD50 subcutaneous 370mg/kg (370mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 979, 1987.