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Substance Name: Methaphenilene hydrochloride [NF]
RN: 7084-07-3
UNII: DK0OIL461Z
InChIKey: FWYFIIQCOLEFQP-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H20-N2-S.Cl-H

Molecular Weight

  • 296.864
 
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Names and Synonyms

Name of Substance

  • Methaphenilene hydrochloride
  • Methaphenilene hydrochloride [NF]

Synonyms

  • Diatrine
  • Diatrine hydrochloride
  • Enstamine
  • Insomin
  • Methaphenilen hydrochloride
  • Methaphenilene HCl
  • Methaphenilene hydrochloride
  • Nilistine
  • NSC 516334
  • UNII-DK0OIL461Z
  • W 50 hydrochloride

Systematic Names

  • 1,2-Ethanediamine, N,N-dimethyl-N'-phenyl-N'-(2-thienylmethyl)-, monohydrochloride (9CI)
  • Ethylenediamine, N,N-dimethyl-N'-phenyl-N'-2-thenyl-, monohydrochloride
  • N,N-Dimethyl-N'-(alpha-thenyl)-N'-phenethylenediamine hydrochloride

Registry Numbers

CAS Registry Number

  • 7084-07-3

FDA UNII

  • DK0OIL461Z

Related Registry Number

  • 493-78-7 (Parent)

System Generated Number

  • 0007084073

Molecular Formulas

Molecular Formula

  • C15-H20-N2-S.Cl-H

Molecular Formula Fragments

  • C15-H20-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H20N2S.ClH/c1-16(2)10-11-17(13-15-9-6-12-18-15)14-7-4-3-5-8-14;/h3-9,12H,10-11,13H2,1-2H3;1H

InChIKey

FWYFIIQCOLEFQP-UHFFFAOYSA-N

Smiles

N(c1ccccc1)(Cc1cccs1)CC[NH+](C)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 30mg/kg (30mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
guinea pig LD50 oral 900mg/kg (900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
guinea pig LD50 subcutaneous 140mg/kg (140mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 939, 1989.
mouse LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
mouse LD50 oral 550mg/kg (550mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
mouse LD50 subcutaneous 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
rabbit LD50 intravenous 30mg/kg (30mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.