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Substance Name: Nafimidone hydrochloride [USAN]
RN: 70891-37-1
UNII: LU0A7HD640
InChIKey: DOBNXXMVNHWJKU-UHFFFAOYSA-N

Classification Codes

  • Anticonvulsant
  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H12-N2-O.Cl-H

Molecular Weight

  • 272.734
 
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Names and Synonyms

Name of Substance

  • Nafimidone hydrochloride [USAN]

Synonyms

  • 1-(2-Naphthoylmethyl)imidazole hydrochloride
  • 2'-Acetonaphthone, 2-(1-imidazolyl)-, hydrochloride
  • 2-(1-Imidazolylacetyl)naphthalene hydrochloride
  • 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone monohydrochloride
  • 2-Imidazol-1-yl-2'-acetonaphthone monohydrochloride
  • Nafimidone HCl
  • Nafimidone hydrochloride
  • RS 81943
  • UNII-LU0A7HD640

Systematic Name

  • Ethanone, 2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 70891-37-1

FDA UNII

  • LU0A7HD640

Related Registry Number

  • 64212-22-2 (Parent)

System Generated Number

  • 0070891371

Molecular Formulas

Molecular Formula

  • C15-H12-N2-O.Cl-H

Molecular Formula Fragments

  • C15-H12-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H12N2O.ClH/c18-15(10-17-8-7-16-11-17)14-6-5-12-3-1-2-4-13(12)9-14;/h1-9,11H,10H2;1H

InChIKey

DOBNXXMVNHWJKU-UHFFFAOYSA-N

Smiles

c12c(ccc(c1)C(Cn1ccnc1)=O)cccc2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 210mg/kg (210mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Bollettino Chimico Farmaceutico. Vol. 120, Pg. 185, 1981.
mouse LD50 oral 420mg/kg (420mg/kg)   Bollettino Chimico Farmaceutico. Vol. 120, Pg. 185, 1981.
rat LD50 oral 504mg/kg (504mg/kg)   Journal of Medicinal Chemistry. Vol. 29, Pg. 1577, 1986.