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Substance Name: Etilefrine [INN:BAN]
RN: 709-55-7
UNII: ZB6F8MY53V
InChIKey: SQVIAVUSQAWMKL-UHFFFAOYSA-N
Note
- A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.
Molecular Formula
- C10-H15-N-O2
Molecular Weight
- 181.2335
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-Agonists
- Adrenergic beta-1 Receptor Agonists
- Adrenergic beta-Agonists
- Autonomic Agents
- Cardiotonic Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Protective Agents
- Reproductive Effect
- Sympathomimetics
- Vasoconstrictor Agents
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Names and Synonyms
Name of Substance
- Etilefrin
- Etilefrine
- Etilefrine [INN:BAN]
MeSH Heading
- Etilefrine
Synonyms
- (+-)-Etilefrin
- (+-)-Etilefrine
- 1-(3'-Hydroxyphenyl)-2-ethylaminoethanol
- 1-(3-Hydroxyphenyl)-2-(ethylamino)ethanol
- alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
- alpha-(m-Hydroxyphenyl)-beta-(ethylamino)ethanol
- Benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-
- Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-
- EC 211-910-4
- Effortil
- EINECS 211-910-4
- Ethyl noradrianol
- Ethyladrianol
- Ethylphenylephrine
- Etilefrin
- Etilefrina
- Etilefrina [DCIT]
- Etilefrina [Spanish]
- Etilefrine
- Etilefrinum
- Etilefrinum [INN-Latin]
- Etilefrinum [Latin]
- Etilephrine
- m-Hydroxy-alpha-(ethylaminomethyl)benzyl alcohol
- m-Hydroxyphenylethanolethylamine
- N-Ethylnorphenylephrine
- Racemic etilefrine
- S 40032
- S 40032-7
- UNII-ZB6F8MY53V
Systematic Names
- alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
- Benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-
- Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-
- Etilefrine
Registry Numbers
CAS Registry Number
- 709-55-7
FDA UNII
- ZB6F8MY53V
Other Registry Number
- 10128-36-6
Related Registry Numbers
- 42145-91-5 (pivalate hydrochloride)
- 943-17-9 (hydrochloride)
System Generated Number
- 0000709557
Structure Descriptors
InChI
InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3InChIKey
SQVIAVUSQAWMKL-UHFFFAOYSA-NSmiles
CCNCC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 36800ug/kg (36.8mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
mouse | LD50 | oral | 770mg/kg (770mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 869, 1972. | |
mouse | LD50 | subcutaneous | 1428mg/kg (1428mg/kg) | Pharmaceutical Chemistry Journal Vol. 22, Pg. 857, 1988. | |
rat | LD50 | intraduodenal | 200mg/kg (200mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | intraperitoneal | 820mg/kg (820mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 27, 1969. |
rat | LD50 | oral | 114mg/kg (114mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | subcutaneous | 244mg/kg (244mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 147.5 | deg C | EXP | |
log P (octanol-water) | 0.280 | (none) | EST | |
Atmospheric OH Rate Constant | 1.70E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.