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Substance Name: Benzene
RN: 71-43-2
UNII: J64922108F
InChIKey: UHOVQNZJYSORNB-UHFFFAOYSA-N
Note
- Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Molecular Formula
- C6-H6
Molecular Weight
- 78.1134
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Out-Dated Pesticide
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- 2007 CERCLA Priority List, Rank: 6
- 2011 CERCLA Priority List, Rank: 6
- Known to be a Carcinogen
- Overall Carcinogenic Evaluation: Group 1
- Reportable Quantity (RQ) = 10 lb
- TWA 0.5 ppm; STEL 2.5 ppm; skin; Confirmed human carcinogen; BEI
- TWA see 1910.1028; Also see Table Z-2 for the limits applicable in the operations or sectors excluded in 1910.1028
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Names and Synonyms
Name of Substance
- Benzene
MeSH Heading
- Benzene
Synonyms
- (6)Annulene
- AI3-00808
- Benzeen
- Benzeen [Dutch]
- Benzen
- Benzen [Polish]
- Benzene
- Benzin
- Benzin (Obs.)
- Benzine
- Benzine (Obs.)
- Benzol
- Benzol 90
- Benzole
- Benzolene
- Benzolo
- Benzolo [Italian]
- Bicarburet of hydrogen
- Carbon oil
- Caswell No. 077
- CCRIS 70
- Coal naphtha
- Cyclohexatriene
- EC 200-753-7
- EINECS 200-753-7
- EPA Pesticide Chemical Code 008801
- Fenzen
- Fenzen [Czech]
- HSDB 35
- Mineral naphtha
- Motor benzol
- NCI-C55276
- Nitration benzene
- NSC 67315
- Phene
- Phenyl hydride
- Polystream
- Pyrobenzol
- Pyrobenzole
- RCRA waste number U019
- UN 1114
- UNII-J64922108F
Systematic Names
- Benzene
- Benzene, pure
Superlist Names
- Benzene
- Benzene (including benzene from gasoline)
- Benzene [UN1114] [Flammable liquid]
- Benzol diluent
- RCRA waste no. U109
- UN1114
Registry Numbers
CAS Registry Number
- 71-43-2
FDA UNII
- J64922108F
Other Registry Numbers
- 1053658-43-7
- 1173023-23-8
- 174973-66-1
- 54682-86-9
System Generated Number
- 0000071432
Structure Descriptors
InChI
InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6HInChIKey
UHOVQNZJYSORNB-UHFFFAOYSA-NSmiles
c1ccccc1Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LCLo | inhalation | 170000mg/m3 (170000mg/m3) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 324, 1955. | |
dog | LCLo | inhalation | 146000mg/m3 (146000mg/m3) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 324, 1955. | |
dog | LDLo | oral | 2gm/kg (2000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935. | |
frog | LDLo | subcutaneous | 1400mg/kg (1400mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935. | |
guinea pig | LD50 | skin | > 9400uL/kg (9.4mL/kg) | Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. | |
guinea pig | LDLo | intraperitoneal | 527mg/kg (527mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 42, 1955. | |
human | LCLo | inhalation | 65mg/m3/5Y (65mg/m3) | BLOOD: OTHER CHANGES | Archiv fuer Geschwulstforschung. Vol. 44, Pg. 145, 1974. |
human | LCLo | inhalation | 2pph/5M (20000ppm) | Tabulae Biologicae. Vol. 3, Pg. 231, 1933. | |
human | TCLo | inhalation | 100ppm (100ppm) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Industrial Medicine. Vol. 17, Pg. 199, 1948. |
mammal (species unspecified) | LCLo | inhalation | 20000ppm/5M (20000ppm) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928. | |
mammal (species unspecified) | LD50 | oral | 5700mg/kg (5700mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. | |
mammal (species unspecified) | LDLo | intraperitoneal | 1500mg/kg (1500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | American Journal of Hygiene. Vol. 7, Pg. 276, 1927. |
man | LDLo | oral | 50mg/kg (50mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980. | |
man | LDLo | unreported | 194mg/kg (194mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TCLo | inhalation | 150ppm/1Y-I (150ppm) | Blut. Vol. 28, Pg. 293, 1974. | |
man | TCLo | inhalation | 150ppm/1Y-I (150ppm) | BLOOD: OTHER CHANGES | Blut. Vol. 28, Pg. 293, 1974. |
mouse | LC50 | inhalation | 9980ppm (9980ppm) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 366, 1943. |
mouse | LD50 | intraperitoneal | 340mg/kg (340mg/kg) | Annals of the New York Academy of Sciences. Vol. 243, Pg. 104, 1975. | |
mouse | LD50 | oral | 4700mg/kg (4700mg/kg) | Hygiene and Sanitation Vol. 32(3), Pg. 349, 1967. | |
mouse | LD50 | skin | 48mg/kg (48mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 5, 1974. | |
rabbit | LCLo | inhalation | 45000ppm/30M (45000ppm) | Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944. | |
rabbit | LD50 | skin | > 9400uL/kg (9.4mL/kg) | Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. | |
rabbit | LDLo | intravenous | 88mg/kg (88mg/kg) | SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE GASTROINTESTINAL: GASTRITIS | Journal of Toxicology and Environmental Health. Vol. (Suppl, |
rat | LC50 | inhalation | 10000ppm/7H (10000ppm) | "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960Vol. -, Pg. 113, 1960. | |
rat | LD50 | intraperitoneal | 1100ug/kg (1.1mg/kg) | Acta Physiologica Polonica. Vol. 12, Pg. 173, 1961. | |
rat | LD50 | oral | 930mg/kg (930mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology and Applied Pharmacology. Vol. 7, Pg. 767, 1965. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 5.5 | deg C | EXP | |
Boiling Point | 80 | deg C | EXP | |
log P (octanol-water) | 2.13 | (none) | EXP | |
Water Solubility | 1790 | mg/L | 25 | EXP |
Vapor Pressure | 94.8 | mm Hg | 25 | EXP |
Henry's Law Constant | 0.00555 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 1.23E-12 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.