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Substance Name: Benzene
RN: 71-43-2
UNII: J64922108F
InChIKey: UHOVQNZJYSORNB-UHFFFAOYSA-N

Note

  • Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

Molecular Formula

  • C6-H6

Molecular Weight

  • 78.1134
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Out-Dated Pesticide
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 6
  • 2011 CERCLA Priority List, Rank: 6
  • Known to be a Carcinogen
  • Overall Carcinogenic Evaluation: Group 1
  • Reportable Quantity (RQ) = 10 lb
  • TWA 0.5 ppm; STEL 2.5 ppm; skin; Confirmed human carcinogen; BEI
  • TWA see 1910.1028; Also see Table Z-2 for the limits applicable in the operations or sectors excluded in 1910.1028

Names and Synonyms

Name of Substance

  • Benzene

MeSH Heading

  • Benzene

Synonyms

  • (6)Annulene
  • AI3-00808
  • Benzeen
  • Benzeen [Dutch]
  • Benzen
  • Benzen [Polish]
  • Benzene
  • Benzin
  • Benzin (Obs.)
  • Benzine
  • Benzine (Obs.)
  • Benzol
  • Benzol 90
  • Benzole
  • Benzolene
  • Benzolo
  • Benzolo [Italian]
  • Bicarburet of hydrogen
  • Carbon oil
  • Caswell No. 077
  • CCRIS 70
  • Coal naphtha
  • Cyclohexatriene
  • EC 200-753-7
  • EINECS 200-753-7
  • EPA Pesticide Chemical Code 008801
  • Fenzen
  • Fenzen [Czech]
  • HSDB 35
  • Mineral naphtha
  • Motor benzol
  • NCI-C55276
  • Nitration benzene
  • NSC 67315
  • Phene
  • Phenyl hydride
  • Polystream
  • Pyrobenzol
  • Pyrobenzole
  • RCRA waste number U019
  • UN 1114
  • UNII-J64922108F

Systematic Names

  • Benzene
  • Benzene, pure

Superlist Names

  • Benzene
  • Benzene (including benzene from gasoline)
  • Benzene [UN1114] [Flammable liquid]
  • Benzol diluent
  • RCRA waste no. U109
  • UN1114

Registry Numbers

CAS Registry Number

  • 71-43-2

FDA UNII

  • J64922108F

Other Registry Numbers

  • 1053658-43-7
  • 1173023-23-8
  • 174973-66-1
  • 54682-86-9

System Generated Number

  • 0000071432

Structure Descriptors

InChI

InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H

InChIKey

UHOVQNZJYSORNB-UHFFFAOYSA-N

Smiles

c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 170000mg/m3 (170000mg/m3)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 324, 1955.
dog LCLo inhalation 146000mg/m3 (146000mg/m3)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 324, 1955.
dog LDLo oral 2gm/kg (2000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935.
frog LDLo subcutaneous 1400mg/kg (1400mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935.
guinea pig LD50 skin > 9400uL/kg (9.4mL/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965.
guinea pig LDLo intraperitoneal 527mg/kg (527mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 42, 1955.
human LCLo inhalation 65mg/m3/5Y (65mg/m3) BLOOD: OTHER CHANGES Archiv fuer Geschwulstforschung. Vol. 44, Pg. 145, 1974.
human LCLo inhalation 2pph/5M (20000ppm)   Tabulae Biologicae. Vol. 3, Pg. 231, 1933.
human TCLo inhalation 100ppm (100ppm) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING		 Industrial Medicine. Vol. 17, Pg. 199, 1948.
mammal (species unspecified) LCLo inhalation 20000ppm/5M (20000ppm)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.
mammal (species unspecified) LD50 oral 5700mg/kg (5700mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mammal (species unspecified) LDLo intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: IRRITABILITY

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)		 American Journal of Hygiene. Vol. 7, Pg. 276, 1927.
man LDLo oral 50mg/kg (50mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.
man LDLo unreported 194mg/kg (194mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TCLo inhalation 150ppm/1Y-I (150ppm)   Blut. Vol. 28, Pg. 293, 1974.
man TCLo inhalation 150ppm/1Y-I (150ppm) BLOOD: OTHER CHANGES Blut. Vol. 28, Pg. 293, 1974.
mouse LC50 inhalation 9980ppm (9980ppm) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 366, 1943.
mouse LD50 intraperitoneal 340mg/kg (340mg/kg)   Annals of the New York Academy of Sciences. Vol. 243, Pg. 104, 1975.
mouse LD50 oral 4700mg/kg (4700mg/kg)   Hygiene and Sanitation Vol. 32(3), Pg. 349, 1967.
mouse LD50 skin 48mg/kg (48mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 5, 1974.
rabbit LCLo inhalation 45000ppm/30M (45000ppm)   Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944.
rabbit LD50 skin > 9400uL/kg (9.4mL/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965.
rabbit LDLo intravenous 88mg/kg (88mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

GASTROINTESTINAL: GASTRITIS		 Journal of Toxicology and Environmental Health. Vol. (Suppl,
rat LC50 inhalation 10000ppm/7H (10000ppm)   "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960Vol. -, Pg. 113, 1960.
rat LD50 intraperitoneal 1100ug/kg (1.1mg/kg)   Acta Physiologica Polonica. Vol. 12, Pg. 173, 1961.
rat LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Toxicology and Applied Pharmacology. Vol. 7, Pg. 767, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 5.5 deg C   EXP
Boiling Point 80 deg C   EXP
log P (octanol-water) 2.13 (none)   EXP
Water Solubility 1790 mg/L 25 EXP
Vapor Pressure 94.8 mm Hg 25 EXP
Henry's Law Constant 0.00555 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.23E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.