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Substance Name: Spermine
RN: 71-44-3
UNII: 2FZ7Y3VOQX
InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N

Note

  • A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.

Molecular Formula

  • C10-H26-N4

Molecular Weight

  • 202.343
 

Classification Code

  • Mutation Data
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Names and Synonyms

Name of Substance

  • Spermine

MeSH Heading

  • Spermine

Synonyms

  • 1,4-Bis(aminopropyl) butanediamine
  • 1,4-Bis(aminopropyl)butanediamine
  • 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)-
  • 4,9-Diaza-1,12-dodecanediamine
  • 4-04-00-01301 (Beilstein Handbook Reference)
  • AI3-26633
  • BRN 1750791
  • Diaminopropyltetramethylenediamine
  • EINECS 200-754-2
  • Gerontine
  • Musculamine
  • N,N'-Bis(3-aminopropyl)-1,4-butanediamine
  • Neuridine
  • NSC 268508
  • Spermin
  • Spermina
  • Spermina [Italian]
  • Spermine
  • Spermine, puriss
  • UNII-2FZ7Y3VOQX

Systematic Names

  • 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
  • 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-
  • 4,9-Diazadodecamethylenediamine

Registry Numbers

CAS Registry Number

  • 71-44-3

FDA UNII

  • 2FZ7Y3VOQX

Other Registry Numbers

  • 1127437-73-3
  • 115-04-8

System Generated Number

  • 0000071443

Structure Descriptors

InChI

1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

InChIKey

PFNFFQXMRSDOHW-UHFFFAOYSA-N

Smiles

C(CCNCCCN)CNCCCN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD30 oral 650mg/kg (650mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984.
mouse LD30 oral 650mg/kg (650mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984.
mouse LD30 subcutaneous 280mg/kg (280mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00641,
mouse LDLo intraperitoneal 8mg/kg (8mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
rat LD50 intraperitoneal 33mg/kg (33mg/kg)   Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987.
rat LD50 intraperitoneal 33mg/kg (33mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987.
rat LD50 intravenous 65mg/kg (65mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 374, 1967.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 29 deg C   EXP
log P (octanol-water) -0.680 (none)   EST
Atmospheric OH Rate Constant 2.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.