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Substance Name: Hydromorphone hydrochloride [USP]
RN: 71-68-1
UNII: L960UP2KRW
InChIKey: XHILEZUETWRSHC-NRGUFEMZSA-N

Note

  • An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Molecular Formula

  • C17-H19-N-O3.Cl-H

Molecular Weight

  • 321.802
 

Classification Codes

Classification Codes

  • Analgesic (Narcotic)
  • Drug / Therapeutic Agent
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Hydromorphone hydrochloride [USP]

Synonyms

  • 4,5-alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride
  • 4,5alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride
  • Dihydromorphinone hydrochloride
  • Dilaudid
  • Dilaudid hydrochloride
  • Dilaudid-HP
  • EINECS 200-762-6
  • Exalgo
  • Hydromorphone HCl
  • Hydromorphone hydrochloride
  • Hymorphan
  • Morphinone, dihydro-, hydrochloride
  • NSC 117862
  • Palladone
  • Tubex
  • UNII-L960UP2KRW

Systematic Names

  • Hydromorphone hydrochloride
  • Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5'-alpha)-
  • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5alpha)-
  • Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride (8CI)

Superlist Names

  • DEA No. 9150
  • Dilaudid

Registry Numbers

CAS Registry Number

  • 71-68-1

FDA UNII

  • L960UP2KRW

System Generated Number

  • 0000071681

Molecular Formulas

Molecular Formula

  • C17-H19-N-O3.Cl-H

Molecular Formula Fragments

  • C17-H19-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1

InChIKey

XHILEZUETWRSHC-NRGUFEMZSA-N

Smiles

Cl.CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
mouse LD50 intravenous 55mg/kg (55mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964.
mouse LD50 subcutaneous 120mg/kg (120mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953.
rabbit LDLo intravenous 2500ug/kg (2.5mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
rat LD50 subcutaneous 51mg/kg (51mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953.