Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Thiopental sodium [USP:INN:JAN]
RN: 71-73-8
UNII: 49Y44QZL70
InChIKey: AWLILQARPMWUHA-UHFFFAOYSA-M

Note

  • A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

Molecular Formula

  • C11-H18-N2-O2-S.Na

Molecular Weight

  • 264.323
 

Classification Codes

Classification Codes

  • Anesthetic (Intravenous)
  • Anticonvulsant
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule III
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Thiopental sodium [USP:INN:JAN]

Synonyms

  • 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt, (+-)-
  • 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid monosodium
  • EINECS 200-763-1
  • Farmotal
  • Hypnostan
  • Intraval sodium
  • Leopental
  • Monosodium 5-ethyl-5-(1-methylbutyl) thiobarbiturate
  • Nesdonal
  • Nesdonal sodium
  • Penthiobarbital sodium
  • Pentothal
  • Pentothal sodium
  • Ravonal
  • Sodium (+-)-5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate
  • Sodium 5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate
  • Sodium penthiobarbital
  • Sodium pentothal
  • Sodium pentothiobarbital
  • Sodium thiopental
  • Sodium thiopentobarbital
  • Sodium thiopentone
  • Soluble thiopentone
  • Thiomebumal sodium
  • Thiomebumalnatrium
  • Thiopental sodique
  • Thiopental sodique [INN-French]
  • Thiopental sodium
  • Thiopental sodium salt
  • Thiopentalum natricum
  • Thiopentalum natricum [INN-Latin]
  • Thiopentalum solubile
  • Thiopentalum-natrium
  • Thiopenton-natrium
  • Thiopentone sodium
  • Thiothal sodium
  • Tiopental sodico
  • Tiopental sodico [INN-Spanish]
  • Tiopental sodium
  • Tiopentale sodico
  • Tiopentale sodico [DCIT]
  • Trapanal
  • Trapanal sodium
  • UNII-49Y44QZL70

Systematic Names

  • 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt
  • Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium salt
  • Thiopental sodium

Superlist Names

  • DEA No. 2100
  • Pentothal

Registry Numbers

CAS Registry Number

  • 71-73-8

FDA UNII

  • 49Y44QZL70

Other Registry Numbers

  • 51259-80-4
  • 7438-31-5

System Generated Number

  • 0000071738

Molecular Formulas

Molecular Formula

  • C11-H18-N2-O2-S.Na

Molecular Formula Fragments

  • C11-H18-N2-O2-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1

InChIKey

AWLILQARPMWUHA-UHFFFAOYSA-M

Smiles

C1([C@@](C(N=C(N1)[S-])=O)([C@@H](CCC)C)CC)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 32500ug/kg (32.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 82, Pg. 212, 1953.
dog LD50 intravenous 36mg/kg (36mg/kg)   Current Researches in Anesthesia and Analgesia. Vol. 29, Pg. 89, 1950.
dog LDLo oral 150mg/kg (150mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
guinea pig LD50 intraperitoneal 57500ug/kg (57.5mg/kg)   Anesthesiology. Vol. 8, Pg. 589, 1947.
human TDLo intraarterial 7mg/kg (7mg/kg) VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE

VASCULAR: ACUTE ARTERIAL OCCLUSION
Lancet. Vol. 2, Pg. 571, 1943.
human TDLo rectal 45mg/kg (45mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Anesthesia and Analgesia Vol. 46, Pg. 395, 1967.
mouse LD50 intraperitoneal 115mg/kg (115mg/kg)   Drugs in Japan Vol. 6, Pg. 457, 1982.
mouse LD50 intravenous 57mg/kg (57mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 221, 1956.
mouse LD50 oral 208mg/kg (208mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 432, 1955.
mouse LD50 subcutaneous 225mg/kg (225mg/kg)   Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974.
rabbit LD50 intraperitoneal 35mg/kg (35mg/kg)   Drugs in Japan Vol. 6, Pg. 457, 1982.
rabbit LD50 intravenous 31mg/kg (31mg/kg)   Current Researches in Anesthesia and Analgesia. Vol. 29, Pg. 89, 1950.
rat LD50 intraperitoneal 28410ug/kg (28.41mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 509, 1940.
rat LD50 intravenous 43600ug/kg (43.6mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 317, 1956.
rat LD50 oral 117mg/kg (117mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 432, 1955.
rat LD50 rectal 102mg/kg (102mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: GENERAL ANESTHETIC
Anesthesia and Analgesia Vol. 46, Pg. 395, 1967.
women TDLo rectal 107mg/kg (107mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)"
Clinical Toxicology. Vol. 2, Pg. 75, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.360 (none)   EST
Atmospheric OH Rate Constant 2.15E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.