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Substance Name: Bucindolol [INN:BAN]
RN: 71119-11-4
UNII: E9UO06K7CE
InChIKey: FBMYKMYQHCBIGU-UHFFFAOYSA-N

Note

  • An indolyl-tert-butyl-phenoxypropanolamine benzonitrile derivative.

Molecular Formula

  • C22-H25-N3-O2

Molecular Weight

  • 363.4585
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympathomimetics
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Bucindolol
  • Bucindolol [INN:BAN]

Synonyms

  • 2-(2-Hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)benzonitrile
  • Bucindolol
  • Bucindololum
  • Bucindololum [INN-Latin]
  • Gencaro
  • UNII-E9UO06K7CE

Systematic Name

  • Benzonitrile, 2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)-

Registry Numbers

CAS Registry Number

  • 71119-11-4

FDA UNII

  • E9UO06K7CE

System Generated Number

  • 0071119114

Structure Descriptors

InChI

1S/C22H25N3O2/c1-22(2,11-17-13-24-20-9-5-4-8-19(17)20)25-14-18(26)15-27-21-10-6-3-7-16(21)12-23/h3-10,13,18,24-26H,11,14-15H2,1-2H3

InChIKey

FBMYKMYQHCBIGU-UHFFFAOYSA-N

Smiles

CC(C)(Cc1c[nH]c2c1cccc2)NCC(COc3ccccc3C#N)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 9600ug/kg (9.6mg/kg)   European Patent Application. Vol. #0065295,
rat LD50 intravenous 20200ug/kg (20.2mg/kg)   European Patent Application. Vol. #0065295,