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Substance Name: Meloxicam [USAN:USP:INN:BAN]
RN: 71125-38-7
UNII: VG2QF83CGL
InChIKey: ZRVUJXDFFKFLMG-UHFFFAOYSA-N

Note

  • NCI: An oxicam derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Unlike traditional nonselective NSAIDs, meloxicam preferentially inhibits the activity of cyclo-oxygenase II (COX-II), resulting in a decreased conversion of arachidonic acid into prostaglandin precursors. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of meloxicam. (NCI Thesaurus)

Molecular Formula

  • C14-H13-N3-O4-S2

Molecular Weight

  • 351.4057
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory (Nonsteroidal)
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Meloxicam
  • Meloxicam [USAN:USP:INN:BAN]

Synonyms

  • CCRIS 9139
  • Coxflam
  • Coxicam
  • HSDB 7741
  • Maxicam
  • Melfax
  • Melonex
  • Meloxicam
  • Meloxicamum
  • Meloxicamum [Latin]
  • Meloxivet
  • Metacam
  • Mobec
  • Mobic
  • Mobicox
  • Movalis
  • Movatec
  • Revmoksikam
  • UH-AC 62XX
  • UNII-VG2QF83CGL
  • Vivlodex

Systematic Names

  • 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methylthiazolyl)-, 1,1-dioxide
  • 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Registry Numbers

CAS Registry Number

  • 71125-38-7

FDA UNII

  • VG2QF83CGL

Other Registry Number

  • 133687-22-6

System Generated Number

  • 0071125387

Structure Descriptors

InChI

1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

InChIKey

ZRVUJXDFFKFLMG-UHFFFAOYSA-N

Smiles

Cc1cnc(s1)NC(=O)C2=C(c3ccccc3S(=O)(=O)N2C)O

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 254 dec deg C   EXP
pKa Dissociation Constant 4.08 (none)   EXP
log P (octanol-water) 3.43 (none)   EXP
Water Solubility 7.150 mg/L 25 EST
Vapor Pressure 1.07E-15 mm Hg 25 EST
Henry's Law Constant 1.74E-19 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.10E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.