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Substance Name: Moclobemide [USAN:INN:BAN]
RN: 71320-77-9
UNII: PJ0Y7AZB63
InChIKey: YHXISWVBGDMDLQ-UHFFFAOYSA-N

Note

  • A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.

Molecular Formula

  • C13-H17-Cl-N2-O2

Molecular Weight

  • 268.742
 

Classification Codes

  • Antidepressant
  • Antidepressive Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Monoamine Oxidase Inhibitors
  • Psychotropic Drugs

Names and Synonyms

Name of Substance

  • Moclobemide
  • Moclobemide [USAN:INN:BAN]

MeSH Heading

  • Moclobemide

Synonyms

  • 4-Chlor-N-(2-morpholinoethyl)benzamid
  • 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide
  • Aurorix
  • Benzamide, 4-chloro-N-(2-(4-morpholinyl)ethyl)-
  • BRN 0530974
  • HSDB 7180
  • Manerix
  • Moclobemid
  • Moclobemida
  • Moclobemida [INN-Spanish]
  • Moclobemide
  • Moclobemidum
  • Moclobemidum [INN-Latin]
  • p-Chloro-N-(2-morpholinoethyl)benzamide
  • Ro 11-1163
  • Ro 11-1163/000
  • UNII-PJ0Y7AZB63

Systematic Name

  • Benzamide, 4-chloro-N-(2-(4-morpholinyl)ethyl)-

Registry Numbers

CAS Registry Number

  • 71320-77-9

FDA UNII

  • PJ0Y7AZB63

System Generated Number

  • 0071320779

Structure Descriptors

InChI

1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)

InChIKey

YHXISWVBGDMDLQ-UHFFFAOYSA-N

Smiles

c1(C(NCCN2CCOCC2)=O)ccc(Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 45mg/kg/2W-I (45mg/kg) BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN)

BEHAVIORAL: MUSCLE WEAKNESS
Human Psychopharmacology. Vol. 13, Pg. 377, 1998.
mouse LD oral > 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 284, Pg. 983, 1998.
mouse LD50 intraperitoneal 591mg/kg (591mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 31, Pg. 909, 1996.
rat LD50 oral 707mg/kg (707mg/kg)   United States Patent Document. Vol. #4210754,
women TDLo oral 5mg/kg/5W-I (5mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Human Psychopharmacology. Vol. 12, Pg. 81, 1997.
women TDLo oral 19mg/kg (19mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SLEEP

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Clinical Psychiatry. Vol. 47, Pg. 438, 1986.
women TDLo oral 66mg/kg/11D-I (66mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Lancet. Vol. 346, Pg. 1032, 1995.
women TDLo oral 12600mg/kg/14 (12600mg/kg) BLOOD: LEUKEMIA

BLOOD: THROMBOCYTOPENIA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Lancet. Vol. 347, Pg. 1329, 1996.