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Substance Name: Riodipine [INN]
RN: 71653-63-9
UNII: W12VDB26LB
InChIKey: AZVFIZVKGSPGPK-UHFFFAOYSA-N

Note

  • An antianginal agent.

Molecular Formula

  • C18-H19-F2-N-O5

Molecular Weight

  • 367.3461
 

Classification Codes

  • Anticonvulsants
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Riodipine [INN]
  • Ryodipine

Synonyms

  • 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydropyridine
  • BRN 0498820
  • Dimethyl 4-(o-(difluoromethoxy)phenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Foridon
  • PP-1466
  • Riodipine
  • Riodipino
  • Riodipino [Spanish]
  • Riodipinum
  • Riodipinum [Latin]
  • UNII-W12VDB26LB

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-, dimethyl ester
  • Dimethyl 4-(o-(difluoromethoxy)phenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Registry Numbers

CAS Registry Number

  • 71653-63-9

FDA UNII

  • W12VDB26LB

Other Registry Number

  • 99400-53-0

System Generated Number

  • 0071653639

Structure Descriptors

InChI

1S/C18H19F2NO5/c1-9-13(16(22)24-3)15(14(10(2)21-9)17(23)25-4)11-7-5-6-8-12(11)26-18(19)20/h5-8,15,18,21H,1-4H3

InChIKey

AZVFIZVKGSPGPK-UHFFFAOYSA-N

Smiles

CC1=C(C(C(=C(N1)C)C(=O)OC)c2ccccc2OC(F)F)C(=O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1198mg/kg (1198mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 915, 1985.
dog LD50 oral 1198mg/kg (1198mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 915, 1985.
mouse LD50 intraperitoneal 360mg/kg (360mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 22, Pg. 810, 1988.
mouse LD50 oral 721mg/kg (721mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 672, 1985.
rabbit LD50 oral 209mg/kg (209mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 915, 1985.
rat LD50 oral 6320mg/kg (6320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 915, 1985.