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Substance Name: Denopamine [INN:JAN]
RN: 71771-90-9
UNII: V5F60UPD8P
InChIKey: VHSBBVZJABQOSG-INIZCTEOSA-N

Molecular Formula

  • C18-H23-N-O4

Molecular Weight

  • 317.3827
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic beta-Agonists
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Protective Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Denopamine
  • Denopamine [INN:JAN]

Synonyms

  • (-)-(R)-1-(p-Hydroxyphenyl)-2-((3,4-dimethoxyphenethyl)amino)ethanol
  • (-)-(R)-alpha-(((3,4-Dimethoxyphenethyl)amino)methyl)-p-hydroxybenzyl alcohol
  • Denopamina
  • Denopamina [Spanish]
  • Denopamine
  • Denopaminum
  • Denopaminum [Latin]
  • Kalgut
  • TA 064
  • UNII-V5F60UPD8P

Systematic Names

  • (-)-(R)-alpha-(((3,4-Dimethoxyphenethyl)amino)methyl)-p-hydroxybenzyl alcohol
  • Benzenemethanol, alpha-(((2-(3,4-dimethoxyphenyl)ethyl)amino)methyl)-4-hydroxy-, (R)-

Registry Numbers

CAS Registry Number

  • 71771-90-9

FDA UNII

  • V5F60UPD8P

System Generated Number

  • 0071771909

Structure Descriptors

InChI

1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1

InChIKey

VHSBBVZJABQOSG-INIZCTEOSA-N

Smiles

COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1651mg/kg (1651mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 oral 5672mg/kg (5672mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 700, 1990.
rat LD50 intraperitoneal 1785mg/kg (1785mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 751, 1986.
rat LD50 oral 9369mg/kg (9369mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 751, 1986.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 751, 1986.