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Substance Name: Sulfathiazole [USP:INN:BAN]
RN: 72-14-0
UNII: Y7FKS2XWQH
InChIKey: JNMRHUJNCSQMMB-UHFFFAOYSA-N

Note

  • Antimicrobial; veterinary use against staphylococcal, streptococcal, pasteurella, and shigella infections.

Molecular Formula

  • C9-H9-N3-O2-S2

Molecular Weight

  • 255.3211
 

Classification Codes

  • Anti-Infective Agents
  • Antibacterial
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Sulfathiazole
  • Sulfathiazole [USP:INN:BAN]

Synonyms

  • 2-(p-Aminobenzenesulfonamido)thiazole
  • 2-(p-Aminobenzenesulphonamido)thiazole
  • 2-(Sulfanilylamino)thiazole
  • 2-Sulfanilamidothiazol
  • 2-Sulfanilamidothiazol [German]
  • 2-Sulfanilamidothiazole
  • 2-Sulfonamidothiazole
  • 2090 R.P.
  • 2090 RP
  • 4-Amino-N-2-thiazolylbenzenesulfonamide
  • AI3-01050
  • Azoquimiol
  • Azoseptale
  • Benzenesulfonamide, 4-amino-N-2-thiazolyl-
  • Caswell No. 809B
  • CCRIS 765
  • Cerazol (suspension)
  • Cerazole
  • Chemosept
  • Ciba 3714
  • Cibazol
  • Coco-Thiazole
  • Duatok
  • Dulana
  • EINECS 200-771-5
  • Eleudron
  • EPA Pesticide Chemical Code 077903
  • Estafilol
  • Formosulfathiazole
  • HSDB 4380
  • M&B 760
  • M+B 760
  • N(1)-2-Thiazolylsulfanilamide
  • N(sup 1)-2-Thiazolylsulfanilamide
  • Neostrepsan
  • Norsulfasol
  • Norsulfazol
  • Norsulfazole
  • Norsulfazolum
  • NSC 31812
  • NSC 683531
  • Planomide
  • Poliseptil
  • RP 2090
  • Sanotiazol
  • Septozol
  • Solfatiazolo
  • Solfatiazolo [DCIT]
  • Streptosilthiazole
  • Sulfamul
  • Sulfanilamide, N(1)-2-thiazolyl-
  • Sulfanilamide, N(sup 1)-2-thiazolyl-
  • Sulfanilamidothiazole
  • Sulfathiazol
  • Sulfathiazol [INN-French]
  • Sulfathiazole
  • Sulfathiazolum
  • Sulfathiazolum [INN-Latin]
  • Sulfatiazol
  • Sulfatiazol [INN-Spanish]
  • Sulfocerol
  • Sulphathiazole
  • Sulzol
  • Thiacoccine
  • Thiasulfol
  • Thiazamide
  • Thiozamide
  • UNII-Y7FKS2XWQH
  • USAF SN-9
  • Wintrazole

Systematic Names

  • Benzenesulfonamide, 4-amino-N-2-thiazolyl-
  • Sulfanilamide, N(sup 1)-2-thiazolyl-
  • Sulfanilamide, N1-2-thiazolyl- (8CI)
  • Sulfathiazole

Mixture Names

  • Sultrin
  • Trysul

Registry Numbers

CAS Registry Number

  • 72-14-0

FDA UNII

  • Y7FKS2XWQH

Other Registry Numbers

  • 158269-46-6
  • 6052-33-1
  • 859037-27-7

Related Registry Number

  • 144-74-1 (mono-hydrochloride salt)

System Generated Number

  • 0000072140

Structure Descriptors

InChI

1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)

InChIKey

JNMRHUJNCSQMMB-UHFFFAOYSA-N

Smiles

Nc1ccc(cc1)S(=O)(=O)Nc2nccs2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo unreported 250mg/kg/23D- (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Journal of Pathology and Bacteriology. Vol. 59, Pg. 501, 1947.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 990mg/kg (990mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 164, 1959.
mouse LD50 oral 4500mg/kg (4500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 571, 1971.
mouse LD50 subcutaneous 1450mg/kg (1450mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 164, 1959.
rat LD50 intravenous 1370mg/kg (1370mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat LDLo intraperitoneal 1250mg/kg (1250mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 164, 1959.
rat LDLo parenteral 1gm/kg (1000mg/kg)   Acta Radiologica. Vol. 37, Pg. 258, 1952.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 189 deg C   EXP
pKa Dissociation Constant 7.2 (none)   EXP
log P (octanol-water) 0.05 (none)   EXP
Water Solubility 373 mg/L 25 EXP
Vapor Pressure 4.22E-08 mm Hg 25 EST
Henry's Law Constant 5.85E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.36E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.