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Substance Name: Prednisolone valerate acetate [JAN]
RN: 72064-79-0
UNII: 2JB27QJW3D
InChIKey: JSCBOJPKXCSHLN-LXURLGNESA-N

Note

  • Topical steroid used for skin disease therapy.

Molecular Formula

  • C28-H38-O7

Molecular Weight

  • 485.5933
 

Classification Codes

  • Drug / Therapeutic Agent
  • Hormone
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Acepreval
  • Prednisolone valerate acetate [JAN]

Synonyms

  • 11-beta,17-alpha,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-valerate
  • 21-(Acetyloxy)-11-beta-hydroxy-17-((1-oxopentyl)oxy)pregna-1,4-diene-3,20-dione
  • Acepreval
  • BRN 2713941
  • EINECS 276-312-8
  • Lidomex
  • Prednisolone 17-valerate 21-acetate
  • Prednisolone valerate acetate
  • Prednisolone-17-valerate-21-acetate
  • UNII-2JB27QJW3D

Systematic Names

  • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate
  • 11beta,17alpha,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-valerate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-((1-oxopentyl)oxy)-, (11-beta)-

Registry Numbers

CAS Registry Number

  • 72064-79-0

FDA UNII

  • 2JB27QJW3D

System Generated Number

  • 0072064790

Structure Descriptors

InChI

1S/C28H37O7/c1-5-6-7-24(33)35-28(23(32)16-34-17(2)29)13-11-21-20-9-8-18-14-19(30)10-12-26(18,3)25(20)22(31)15-27(21,28)4/h10,12,14-15,20-22,25,31H,5-9,11,13,16H2,1-4H3/t20-,21-,22-,25+,26-,28-/m0/s1

InChIKey

JSCBOJPKXCSHLN-LXURLGNESA-N

Smiles

CCCCC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C=[C]12C)C(=O)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1360mg/kg (1360mg/kg) BLOOD: CHANGES IN SPLEEN

ENDOCRINE: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.
mouse LD50 oral > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

ENDOCRINE: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.
rabbit LD50 subcutaneous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: HEMORRHAGE

LIVER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1371, 1982.
rat LD50 oral > 4gm/kg (4000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 195, 1980.