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Substance Name: Astromicin Sulfate [USAN:JAN]
RN: 72275-67-3
UNII: POY3S0T3BD
InChIKey: TYNZVWXDLOJTIM-QQFWICJTSA-N

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Natural Product
  • Reproductive Effect

Molecular Formula

  • C17-H35-N5-O6.2H2-O4-S

Molecular Weight

  • 601.6481
 
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Names and Synonyms

Name of Substance

  • Astromicin Sulfate [USAN:JAN]

Synonyms

  • 4-Amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol sulfate (1:2) (salt)
  • Abbott 44747
  • Abbott-44747
  • Astromicin sulfate
  • Fortimicin A sulfate
  • KW-1070 sulfate
  • UNII-POY3S0T3BD
  • XK 70-1 sulfate

Systematic Names

  • L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-, disulfate
  • L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methylsulfate (1:2) (salt)

Registry Numbers

CAS Registry Number

  • 72275-67-3

FDA UNII

  • POY3S0T3BD

Related Registry Number

  • 55779-06-1 (Parent)

System Generated Number

  • 0072275673

Molecular Formulas

Molecular Formula

  • C17-H35-N5-O6.2H2-O4-S

Molecular Formula Fragments

  • C17-H35-N5-O6
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C17H35N5O6.2H2O4S/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18;2*1-5(2,3)4/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3;2*(H2,1,2,3,4)/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+;;/m0../s1

InChIKey

TYNZVWXDLOJTIM-QQFWICJTSA-N

Smiles

CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@@H](CC[C@H]2N)[C@H](C)N)[C@H](O)[C@@H]1N(C)C(=O)CN.OS(=O)(=O)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 750mg/kg (750mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Chemotherapy Vol. 29(Suppl,
dog LD50 intravenous 214mg/kg (214mg/kg)   Chemotherapy Vol. 29(Suppl,
guinea pig LD50 intramuscular 611mg/kg (611mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
mouse LD50 intramuscular 427mg/kg (427mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Chemotherapy Vol. 29(Suppl,
mouse LD50 intraperitoneal 533mg/kg (533mg/kg)   Chemotherapy Vol. 29(Suppl,
mouse LD50 intravenous 94mg/kg (94mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
mouse LD50 oral 13600mg/kg (13600mg/kg)   Chemotherapy Vol. 29(Suppl,
mouse LD50 subcutaneous 546mg/kg (546mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 967, 1985.
rabbit LD50 intravenous 654mg/kg (654mg/kg)   Drugs in Japan Vol. -, Pg. 19, 1995.
rat LD50 intramuscular 1009mg/kg (1009mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
rat LD50 intraperitoneal 913mg/kg (913mg/kg)   Chemotherapy Vol. 29(Suppl,
rat LD50 intravenous 86mg/kg (86mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
rat LD50 oral > 10gm/kg (10000mg/kg)   Chemotherapy Vol. 29(Suppl,
rat LD50 subcutaneous 1364mg/kg (1364mg/kg)   Chemotherapy Vol. 29(Suppl,