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Substance Name: Metoclopramide hydrochloride
RN: 7232-21-5
UNII: 7B1QZY5SWZ
InChIKey: RVFUNJWWXKCWNS-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C14-H22-Cl-N3-O2.Cl-H

Molecular Weight

  • 336.2607
 

Names and Synonyms

Results Name

  • Metoclopramide hydrochloride

Name of Substance

  • Metoclopramide hydrochloride anhydrous

Synonyms

  • 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide hydrochloride
  • CCRIS 7142
  • Cerucal
  • Clopra
  • EINECS 230-634-5
  • Maxolon
  • Metoclopramide
  • Metoclopramide HCl
  • Metoclopramide hydrochloride
  • Metoclopramide intensol
  • Metoclopramide monohydrochloride
  • Metozolv
  • Metozolv ODT
  • NSC 354467
  • Paspertin
  • Primperan (tablet)
  • Reglan
  • Reglan ODT
  • Rimetin
  • UNII-7B1QZY5SWZ

Systematic Names

  • 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride
  • Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride (9CI)
  • Metoclopramide hydrochloride
  • o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 7232-21-5

FDA UNII

  • 7B1QZY5SWZ

Other Registry Number

  • 49625-23-2

Related Registry Number

  • 364-62-5 (Parent)

System Generated Number

  • 0007232215

Molecular Formulas

Molecular Formula

  • C14-H22-Cl-N3-O2.Cl-H

Molecular Formula Fragments

  • C14-H22-Cl-N3-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H

InChIKey

RVFUNJWWXKCWNS-UHFFFAOYSA-N

Smiles

Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 143ug/kg (0.143mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Intensive Care Medicine. Vol. 12, Pg. 378, 1986.
man TDLo multiple routes 85mg/kg/48W-I (85mg/kg) BEHAVIORAL: ATAXIA New England Journal of Medicine. Vol. 315, Pg. 518, 1986.
man TDLo oral 400ug/kg/16H- (0.4mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Anesthesia and Analgesia Vol. 66, Pg. 274, 1987.
man TDLo oral 1mg/kg/2D-I (1mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
British Journal of Clinical Practice. Vol. 28, Pg. 201, 1974.
man TDLo oral 1714ug/kg (1.714mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: REGIDITY
Southern Medical Journal. Vol. 81, Pg. 674, 1988.
man TDLo oral 1161mg/kg/2D- (1161mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Southern Medical Journal. Vol. 76, Pg. 817, 1983.
rat LD50 subcutaneous 475mg/kg (475mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
women TDLo intravenous 15mg/kg/9H-I (15mg/kg)   Clinical Pharmacy. Vol. 5, Pg. 342, 1986.
women TDLo oral 2400ug/kg/3D- (2.4mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: REGIDITY

BEHAVIORAL: TREMOR
Canadian Medical Association Journal. Vol. 126, Pg. 23, 1982.