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Substance Name: Aniracetam [USAN:INN:JAN]
RN: 72432-10-1
UNII: 5L16LKN964
InChIKey: ZXNRTKGTQJPIJK-UHFFFAOYSA-N

Note

  • Mental performance enhancer.

Molecular Formula

  • C12-H13-N-O3

Molecular Weight

  • 219.2387
 

Classification Codes

  • Antidepressive Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Mental Performance Enhancer
  • Nootropic Agents
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Aniracetam
  • Aniracetam [USAN:INN:JAN]

Synonyms

  • 1-(4-Methoxybenzoyl)-2-pyrrolidinone
  • 1-(p-Methoxybenzoyl)-2-pyrrolidinon
  • 1-(p-Methoxybenzoyl)-2-pyrrolidinon [German]
  • 1-p-Anisoyl-2-pyrrolidinone
  • Aniracetam
  • Aniracetamun
  • Aniracetamun [INN-Latin]
  • BRN 4807205
  • Draganon
  • Ro 13-5057
  • Ro 135057
  • Sarpul
  • UNII-5L16LKN964

Systematic Name

  • 2-Pyrrolidinone, 1-(4-methoxybenzoyl)-

Registry Numbers

CAS Registry Number

  • 72432-10-1

FDA UNII

  • 5L16LKN964

System Generated Number

  • 0072432101

Structure Descriptors

InChI

1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3

InChIKey

ZXNRTKGTQJPIJK-UHFFFAOYSA-N

Smiles

COc1ccc(cc1)C(=O)N2CCCC2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1180mg/kg (1180mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
mouse LD50 intravenous > 100mg/kg (100mg/kg)   Medicamentos de Actualidad. Vol. 30, Pg. 9, 1994.
mouse LD50 oral 3648mg/kg (3648mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 45, 1995.
rabbit LD50 oral > 2gm/kg (2000mg/kg)   Medicamentos de Actualidad. Vol. 30, Pg. 9, 1994.
rat LD50 intraperitoneal 1255mg/kg (1255mg/kg)   Medicamentos de Actualidad. Vol. 30, Pg. 9, 1994.
rat LD50 intravenous > 50mg/kg (50mg/kg)   Medicamentos de Actualidad. Vol. 30, Pg. 9, 1994.
rat LD50 oral 4500mg/kg (4500mg/kg)   Psychopharmacology Vol. 78, Pg. 104, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 45, 1995.