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Substance Name: Felodipine [USAN:USP:INN:BAN]
RN: 72509-76-3
UNII: OL961R6O2C
InChIKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N

Note

  • A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.

Molecular Formula

  • C18-H19-Cl2-N-O4

Molecular Weight

  • 384.2571
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Reproductive Effect
  • Vasodilator
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Felodipine
  • Felodipine [USAN:USP:INN:BAN]

MeSH Heading

  • Felodipine

Synonyms

  • (+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Agon
  • Agon SR
  • BRN 4331472
  • dl-Felodipine
  • Feloday
  • Felodipina
  • Felodipina [INN-Spanish]
  • Felodipine
  • Felodipinum
  • Felodipinum [INN-Latin]
  • Felodur ER
  • Felogard
  • Flodil
  • H 154/82
  • Hydac
  • Modip
  • Munobal
  • Munobal Retard
  • Penedil
  • Perfudal
  • Plendil
  • Plendil Depottab
  • Plendil ER
  • Plendil Retard
  • Preslow
  • Prevex
  • Renedil
  • Splendil
  • UNII-OL961R6O2C

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester, (+-)-

Mixture Name

  • Lexxel

Registry Numbers

CAS Registry Number

  • 72509-76-3

FDA UNII

  • OL961R6O2C

Other Registry Number

  • 86189-69-7

System Generated Number

  • 0072509763

Structure Descriptors

InChI

1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChIKey

RZTAMFZIAATZDJ-UHFFFAOYSA-N

Smiles

CCOC(=O)C1=C(NC(=C(C1c2cccc(c2Cl)Cl)C(=O)OC)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 200mg/kg (200mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BLOOD: CHANGES IN SPLEEN
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 2963, 1992.
mouse LD50 intraperitoneal 76mg/kg (76mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse LD50 intravenous 3100ug/kg (3.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse LD50 oral 250mg/kg (250mg/kg)   Cardiovascular Drug Reviews. Vol. 11, Pg. 126, 1993.
mouse LD50 subcutaneous 205mg/kg (205mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 intraperitoneal 23mg/kg (23mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 intravenous 5400ug/kg (5.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 oral 1050mg/kg (1050mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 subcutaneous > 600mg/kg (600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.86 (none)   EXP
Water Solubility 19.7 mg/L 25 EST
Vapor Pressure 4.40E-08 mm Hg 25 EST
Henry's Law Constant 1.35E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.14E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.