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Substance Name: Ceftazidime [INN]
RN: 72558-82-8
UNII: DZR1ENT301
InChIKey: ORFOPKXBNMVMKC-KZBLUZIOSA-N

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C22-H22-N6-O7-S2

Molecular Weight

  • 546.5828
 
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Names and Synonyms

Results Name

  • Ceftazidime [INN]

Name of Substance

  • Ceftazidime anhydrous
  • Ceftazidime [INN]

Synonyms

  • Biotum
  • BRN 4344904
  • Ceftazidime
  • EINECS 276-715-9
  • Fortam
  • Fortaz
  • Fortum
  • GR 20263
  • Modacin
  • SN 401
  • Tizime
  • UNII-DZR1ENT301
  • Zidim

Systematic Names

  • Ceftazidime
  • Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt, (6R-(6-alpha,7-beta-(Z)))-

Registry Numbers

CAS Registry Number

  • 72558-82-8

FDA UNII

  • DZR1ENT301

Other Registry Number

  • 133943-58-5

System Generated Number

  • 0072558828

Structure Descriptors

InChI

1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13+/t14-,18-/m1/s1

InChIKey

ORFOPKXBNMVMKC-KZBLUZIOSA-N

Smiles

C(O\N=C(/c1nc(N)sc1)C(N[C@H]1[C@@H]2N(C1=O)C(=C(C[n+]1ccccc1)CS2)C([O-])=O)=O)(C(=O)O)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 4gm/kg (4000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Chemotherapy Vol. 31(Suppl,
mouse LD50 intraperitoneal 11gm/kg (11000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Chemotherapy Vol. 31(Suppl,
mouse LD50 intravenous 6300mg/kg (6300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Chemotherapy Vol. 31(Suppl,
mouse LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Chemotherapy Vol. 31(Suppl,
mouse LD50 subcutaneous 20gm/kg (20000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rabbit LD50 intramuscular 2gm/kg (2000mg/kg)   Chemotherapy Vol. 31(Suppl,
rabbit LD50 intravenous > 2gm/kg (2000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Chemotherapy Vol. 31(Suppl,
rat LD50 intramuscular > 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 intraperitoneal 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 31(Suppl,
rat LD50 intravenous 5800mg/kg (5800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 subcutaneous 20gm/kg (20000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 31(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.360 (none)   EST
Atmospheric OH Rate Constant 1.31E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.