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Substance Name: Hydrocortisone probutate [USAN]
RN: 72590-77-3
UNII: O6550D6K3A
InChIKey: FOGXJPFPZOHSQS-AYVLZSQQSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Glucocorticoid
  • Hormone
  • Reproductive Effect
  • Skin / Eye Irritant

Molecular Formula

  • C28-H40-O7

Molecular Weight

  • 488.617
 
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Names and Synonyms

Name of Substance

  • Hydrocortisone 17-butyrate 21-propionate
  • Hydrocortisone butyrate propionate [JAN]
  • Hydrocortisone probutate [USAN]

Synonyms

  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
  • 11beta-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)pregn-4-ene-3,20-dione
  • 17-Butyryloxy-11-beta-hydroxy-21-propionyloxy-4-pregnene-3,20-dione
  • EINECS 276-726-9
  • HBP
  • Hydrocortisone 17-butyrate 21-propionate
  • Hydrocortisone buteprate
  • Hydrocortisone butyrate propionate
  • Hydrocortisone probutate
  • Pandel
  • Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)-, (11-beta)-
  • Pregn-4-ene-3,30-dione, 11-beta,17,21-trihydroxy-, 17-butyrate, 21-propionate
  • TS 408
  • UNII-O6550D6K3A

Systematic Names

  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
  • Cortisol, 17-butyrate, 21-propionate
  • Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-(1-oxopropyl)-, (11beta)-

Registry Numbers

CAS Registry Number

  • 72590-77-3

FDA UNII

  • O6550D6K3A

System Generated Number

  • 0072590773

Structure Descriptors

InChI

1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1

InChIKey

FOGXJPFPZOHSQS-AYVLZSQQSA-N

Smiles

CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 877, 1990.
mouse LD50 intraperitoneal 1660mg/kg (1660mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Toxicological Sciences. Vol. 6(Suppl,
mouse LD50 oral 6720mg/kg (6720mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Toxicological Sciences. Vol. 6(Suppl,
mouse LD50 subcutaneous 1980mg/kg (1980mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Toxicological Sciences. Vol. 6(Suppl,
rat LD50 intraperitoneal 1420mg/kg (1420mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Toxicological Sciences. Vol. 6(Suppl,
rat LD50 oral 5120mg/kg (5120mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Toxicological Sciences. Vol. 6(Suppl,
rat LD50 subcutaneous 3260mg/kg (3260mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Toxicological Sciences. Vol. 6(Suppl,