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Substance Name: Tolperisone [INN:BAN]
RN: 728-88-1
UNII: F5EOM0LD8E
InChIKey: FSKFPVLPFLJRQB-UHFFFAOYSA-N

Note

  • A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

Molecular Formula

  • C16-H23-N-O

Molecular Weight

  • 245.364
 

Classification Codes

  • Central Nervous System Agents
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Tolperisone
  • Tolperisone [INN:BAN]

MeSH Heading

  • Tolperisone

Synonyms

  • 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone
  • 2,4'-Dimethyl-3-piperidinopropiophenone
  • 2-Methyl-3-piperidino-1-p-tolylpropan-1-one
  • 5-20-02-00357 (Beilstein Handbook Reference)
  • Atmosgen (free base)
  • Besnoline (free base)
  • BRN 1285666
  • EINECS 211-976-4
  • Menopatol
  • Mideton
  • Mydeton
  • Mydocalm
  • N-553 [as hydrochloride]
  • NSC 107321
  • Roystajin (free base)
  • Tolperisona
  • Tolperisona [INN-Spanish]
  • Tolperisone
  • Tolperisonum
  • Tolperisonum [INN-Latin]
  • UNII-F5EOM0LD8E

Systematic Names

  • 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI)
  • 2,4'-Dimethyl-3-piperidinopropiophenone
  • Propiophenone, 2,4'-dimethyl-3-piperidino-
  • Tolperisone

Registry Numbers

CAS Registry Number

  • 728-88-1

FDA UNII

  • F5EOM0LD8E

System Generated Number

  • 0000728881

Structure Descriptors

InChI

1S/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3

InChIKey

FSKFPVLPFLJRQB-UHFFFAOYSA-N

Smiles

c1(C([C@@H](CN2CCCCC2)C)=O)ccc(C)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 180mg/kg (180mg/kg) BEHAVIORAL: REGIDITY Chemical and Pharmaceutical Bulletin. Vol. 34, Pg. 1634, 1986.
mouse LD50 intravenous 34mg/kg (34mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 421, 1971.
mouse LD50 oral 1350mg/kg (1350mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 421, 1971.
mouse LD50 subcutaneous 620mg/kg (620mg/kg) BEHAVIORAL: ATAXIA Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 257, 1961.
rat LD50 intraperitoneal 170mg/kg (170mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 421, 1971.
rat LD50 oral 1450mg/kg (1450mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 421, 1971.
rat LD50 subcutaneous 645mg/kg (645mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 421, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 176-177 deg C   EXP
log P (octanol-water) 3.65 (none)   EXP
Water Solubility 195 mg/L 25 EST
Vapor Pressure 3.45E-05 mm Hg 25 EST
Henry's Law Constant 9.76E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.33E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.