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Substance Name: Sulfamoxole [USAN:INN:BAN]
RN: 729-99-7
UNII: HGG82XE020
InChIKey: CYFLXLSBHQBMFT-UHFFFAOYSA-N

Note

  • A sulfanilamide antibacterial agent.

Molecular Formula

  • C11-H13-N3-O3-S

Molecular Weight

  • 267.3077
 

Classification Codes

  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Sulfamoxole
  • Sulfamoxole [USAN:INN:BAN]

MeSH Heading

  • Sulfamoxole

Synonyms

  • 2-(p-Aminobenzenesulfonamido)-4,5-dimethyloxazole
  • 2-(p-Aminobenzolsulfonamido)-4,5-dimethyloxazol
  • 2-(p-Aminobenzolsulfonamido)-4,5-dimethyloxazol [German]
  • 4,5-Dimethyl-2-sulfanilamidooxazole
  • 4-Amino-N-(4,5-dimethyl-2-oxazolyl)benzenesulfonamide
  • EINECS 211-982-7
  • Justamil
  • N(sup 1)-(4,5-Dimethyl-2-oxazolyl)sulfanilamide
  • N1-(4,5-Dimethyl-2-oxazolyl)sulfanilamide
  • NSC 683535
  • Oxasulfa
  • Oxazole, 2-(p-aminophenylsulfonylamino)-4,5-dimethyl-
  • p-Aminobenzenesulfonyl-2-amino-4,5-dimethyloxazole
  • Solfamossolo
  • Solfamossolo [DCIT]
  • Sulfabutin
  • Sulfadimethyloxazole
  • Sulfamoxol
  • Sulfamoxol [INN-Spanish]
  • Sulfamoxole
  • Sulfamoxolum
  • Sulfamoxolum [INN-Latin]
  • Sulfavigor
  • Sulfmidil
  • Sulfuno
  • Sulphamoxole
  • Tardamid
  • Tardamide
  • UNII-HGG82XE020

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(4,5-dimethyl-2-oxazolyl)-
  • Sulfamoxole
  • Sulfanilamide, N(sup 1)-(4,5-dimethyl-2-oxazolyl)-

Registry Numbers

CAS Registry Number

  • 729-99-7

FDA UNII

  • HGG82XE020

System Generated Number

  • 0000729997

Structure Descriptors

InChI

1S/C11H13N3O3S/c1-7-8(2)17-11(13-7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)

InChIKey

CYFLXLSBHQBMFT-UHFFFAOYSA-N

Smiles

Cc1c(oc(n1)NS(=O)(=O)c2ccc(cc2)N)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1800mg/kg (1800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 612, 1960.
mouse LD50 oral 15200mg/kg (15200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 612, 1960.
mouse LD50 subcutaneous 1285mg/kg (1285mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 612, 1960.
rat LD50 intraperitoneal 2500mg/kg (2500mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
rat LD50 oral > 12500mg/kg (12500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 193 deg C   EXP
log P (octanol-water) 1.030 (none)   EST
Water Solubility 1680 mg/L 20 EXP
Atmospheric OH Rate Constant 3.24E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.