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Substance Name: Carvedilol [USAN:USP:INN:BAN:JAN]
RN: 72956-09-3
UNII: 0K47UL67F2
InChIKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N

Note

  • Antioxidant with alpha as well as beta blocking activity.

Molecular Formula

  • C24-H26-N2-O4

Molecular Weight

  • 406.4794
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Anginal
  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Reproductive Effect
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Carvedilol
  • Carvedilol [USAN:USP:INN:BAN:JAN]

Synonyms

  • (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol
  • 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-
  • BM 14.190
  • BM 14190
  • Carvedilol
  • Carvedilolum
  • Carvedilolum [Latin]
  • Coreg
  • Dilatrend
  • DQ 2466
  • HSDB 7044
  • SKF 105517
  • UNII-0K47UL67F2

Systematic Name

  • 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-

Registry Numbers

CAS Registry Number

  • 72956-09-3

FDA UNII

  • 0K47UL67F2

Other Registry Number

  • 107741-96-8

System Generated Number

  • 0072956093

Structure Descriptors

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChIKey

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Smiles

COc1ccccc1OCCNCC(COc2cccc3c2c4ccccc4[nH]3)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
mouse LD50 intraperitoneal 364mg/kg (364mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LD50 intravenous 27mg/kg (27mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LDLo oral 8gm/kg (8000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
mouse LDLo oral 8gm/kg (8000mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
rat LD50 intraperitoneal 769mg/kg (769mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LIVER: OTHER CHANGES		 New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LDLo oral 8gm/kg (8000mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 114.5 deg C   EXP
log P (octanol-water) 4.19 (none)   EXP
Water Solubility 0.583 mg/L 25 EST
Vapor Pressure 1.52E-15 mm Hg 25 EST
Henry's Law Constant 2.53E-20 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.48E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.