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Substance Name: Carvedilol [USAN:USP:INN:BAN:JAN]
RN: 72956-09-3
UNII: 0K47UL67F2
InChIKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N
Note
- A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
Molecular Formula
- C24-H26-N2-O4
Molecular Weight
- 406.4794
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Adrenergic beta-Antagonists
- Anti-Anginal
- Antihypertensive
- Antihypertensive Agents
- Antioxidants
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Neurotransmitter Agents
- Protective Agents
- Reproductive Effect
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Carvedilol
- Carvedilol [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Carvedilol
Synonyms
- (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-
- BM 14.190
- BM 14190
- Carvedilol
- Carvedilolum
- Carvedilolum [Latin]
- Coreg
- Dilatrend
- DQ 2466
- HSDB 7044
- NSC 758694
- SKF 105517
- UNII-0K47UL67F2
Systematic Name
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-
Registry Numbers
CAS Registry Number
- 72956-09-3
FDA UNII
- 0K47UL67F2
Other Registry Number
- 107741-96-8
System Generated Number
- 0072956093
Structure Descriptors
InChI
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3InChIKey
OGHNVEJMJSYVRP-UHFFFAOYSA-NSmiles
COc1ccccc1OCCNCC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 1gm/kg (1000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989. |
mouse | LD50 | intraperitoneal | 364mg/kg (364mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987. |
mouse | LD50 | intravenous | 27mg/kg (27mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987. |
mouse | LDLo | oral | 8gm/kg (8000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989. |
rat | LD50 | intraperitoneal | 769mg/kg (769mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987. |
rat | LD50 | intravenous | 25mg/kg (25mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987. |
rat | LDLo | oral | 8gm/kg (8000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989. | |
rat | LDLo | oral | 8gm/kg (8000mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 114.5 | deg C | EXP | |
log P (octanol-water) | 4.19 | (none) | EXP | |
Water Solubility | 0.583 | mg/L | 25 | EST |
Vapor Pressure | 1.52E-15 | mm Hg | 25 | EST |
Henry's Law Constant | 2.53E-20 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.48E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.