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Substance Name: Phentolamine hydrochloride [USP]
RN: 73-05-2
UNII: 86DRW83R1H
InChIKey: TUEJFGFQYKDAPM-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H19-N3-O.Cl-H

Molecular Weight

  • 317.818
 
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Names and Synonyms

Name of Substance

  • Phentolamine hydrochloride [USP]

Synonyms

  • 3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol hydrochloride
  • C-7337
  • EINECS 200-793-5
  • m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monohydrochloride
  • Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride
  • Phentolamine chloride
  • Phentolamine HCl
  • Phentolamine hydrochloride
  • Regitine hydrochloride
  • UNII-86DRW83R1H

Systematic Names

  • Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride
  • Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monohydrochloride (8CI)
  • Phentolamine hydrochloride

Registry Numbers

CAS Registry Number

  • 73-05-2

FDA UNII

  • 86DRW83R1H

Related Registry Number

  • 50-60-2 (Parent)

System Generated Number

  • 0000073052

Molecular Formulas

Molecular Formula

  • C17-H19-N3-O.Cl-H

Molecular Formula Fragments

  • C17-H19-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

InChIKey

TUEJFGFQYKDAPM-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(c3)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 104mg/kg (104mg/kg)   Veterinary and Human Toxicology. Vol. 39, Pg. 214, 1997.
rat LD50 intravenous 75mg/kg (75mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 70, 1949.
rat LD50 oral 1250mg/kg (1250mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 70, 1949.
rat LD50 subcutaneous 275mg/kg (275mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 70, 1949.