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Substance Name: Etozolin [USAN:INN]
RN: 73-09-6
UNII: UEO8UW9V1Z
InChIKey: ZCKKHYXUQFTBIK-KTKRTIGZSA-N

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Natriuretic Agents
  • Reproductive Effect

Molecular Formula

  • C13-H20-N2-O3-S

Molecular Weight

  • 284.378
 
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Names and Synonyms

Name of Substance

  • Etozolin
  • Etozolin [USAN:INN]

Synonyms

  • (3-Methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene)acetic acid ethyl ester
  • 2-Carbethoxymethylene-3-methyl-5-piperidino-4-thiazolidone
  • 3-Methyl-4-oxo-5-piperidino-delta(sup 2,a)-thiazolidineacetic acid ethyl ester
  • 3-Methyl-4-oxo-5-piperidino-delta(sup 2,alpha)-thiazolidineacetic acid ethyl ester
  • 3-Methyl-4-oxo-5-piperidino-delta(sup2, alpha)thiazolidineacetic
  • Acetic acid, (3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene)-, ethyl ester
  • EINECS 200-794-0
  • Elkapin
  • Ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate
  • Etozolin
  • Etozoline
  • Etozoline [INN-French]
  • Etozolino
  • Etozolino [INN-Spanish]
  • Etozolinum
  • Etozolinum [INN-Latin]
  • GO 687
  • NSC 310039
  • UNII-UEO8UW9V1Z
  • W 2900 A
  • W 2900A
  • W2900A
  • Z-(3-Methyl-4-oxo-5-piperidino-thiazolidin-2-yliden)-essigsaeureaethylester
  • Z-(3-Methyl-4-oxo-5-piperidino-thiazolidin-2-yliden)-essigsaeureaethylester [German]

Systematic Names

  • Acetic acid, (3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene)-, ethyl ester
  • Acetic acid, (3-methyl-4-oxo-5-piperidino-2-thiazolidinylidene)-, ethyl ester
  • delta(sup 2,alpha)-Thiazolidineacetic acid, 3-methyl-4-oxo-5-piperidino-, ethyl ester (8CI)
  • delta2,alpha-Thiazolidineacetic acid, 3-methyl-4-oxo-5-piperidino-, ethyl ester (8CI)
  • Ethyl (3-methyl-4-oxo-5-piperidinothiazolidin-2-ylidene)acetate
  • Etozolin

Registry Numbers

CAS Registry Number

  • 73-09-6

FDA UNII

  • UEO8UW9V1Z

System Generated Number

  • 0000073096

Structure Descriptors

InChI

1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9-

InChIKey

ZCKKHYXUQFTBIK-KTKRTIGZSA-N

Smiles

N1([C@@H]2C(N(C)C(\S2)=C/C(OCC)=O)=O)CCCCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 3200mg/kg (3200mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
mouse LD50 intraperitoneal 1210mg/kg (1210mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
mouse LD50 oral 8670mg/kg (8670mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
mouse LDLo intravenous 56600ug/kg (56.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
rat LD50 intraperitoneal 1575mg/kg (1575mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
rat LD50 oral 10250mg/kg (10250mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.
rat LDLo intravenous 110mg/kg (110mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1745, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 140 deg C   EXP
log P (octanol-water) 2.360 (none)   EST
Atmospheric OH Rate Constant 1.96E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.